Aspartames Alter Pharmacokinetics Parameters of Erlotinib and Gefitinib and Elevate Liver Enzymes in Wistar Rats

Background: Erlotinib (ERL) and gefitinib (GEF) are extensively metabolized by CYP450 enzymes. Aspartame (ASP), an artificial sweetener, induces CYP2E1 and CYP3A2 enzymes in the brain and could increase liver enzymes. In this work, the influence of ASP on the pharmacokinetics (PK) of ERL and GEF in...

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Detalles Bibliográficos
Autores principales: AlRasheed, Hajer, Almomen, Aliyah, Aljohar, Haya I., Arafah, Maria, Almotawa, Rana Y., Alossaimi, Manal A., Alzoman, Nourah Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699004/
https://www.ncbi.nlm.nih.gov/pubmed/36422530
http://dx.doi.org/10.3390/ph15111400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699004/
https://www.ncbi.nlm.nih.gov/pubmed/36422530
http://dx.doi.org/10.3390/ph15111400

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