Aberrant Cortical Layer Development of Brain Organoids Derived from Noonan Syndrome-iPSCs

Noonan syndrome (NS) is a genetic disorder mainly caused by gain-of-function mutations in Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2). Although diverse neurological manifestations are commonly diagnosed in NS patients, the mechanisms as to how SHP2 mutations induce the neu...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Bumsoo, Koh, Yongjun, Do, Hyunsu, Ju, Younghee, Choi, Jong Bin, Cho, Gahyang, Yoo, Han-Wook, Lee, Beom Hee, Han, Jinju, Park, Jong-Eun, Han, Yong-Mahn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699065/
https://www.ncbi.nlm.nih.gov/pubmed/36430334
http://dx.doi.org/10.3390/ijms232213861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699065/
https://www.ncbi.nlm.nih.gov/pubmed/36430334
http://dx.doi.org/10.3390/ijms232213861

Ejemplares similares