Design, Synthesis, and Antiprotozoal Evaluation of New Promising 2,9-Bis[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline Derivatives, a Potential Alternative Scaffold to Drug Efflux

A series of novel 2,9-bis[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline derivatives was designed, synthesized, and evaluated in vitro against three protozoan parasites (Plasmodium falciparum, Leishmania donovani and Trypanosoma brucei brucei). Pharmacological results showed antiprotozoal...

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Detalles Bibliográficos
Autores principales: Guillon, Jean, Cohen, Anita, Boudot, Clotilde, Monic, Sarah, Savrimoutou, Solène, Moreau, Stéphane, Albenque-Rubio, Sandra, Lafon-Schmaltz, Camille, Dassonville-Klimpt, Alexandra, Mergny, Jean-Louis, Ronga, Luisa, Bernabeu de Maria, Mikel, Lamarche, Jeremy, Lago, Cristina Dal, Largy, Eric, Gabelica, Valérie, Moukha, Serge, Dozolme, Pascale, Agnamey, Patrice, Azas, Nadine, Mullié, Catherine, Courtioux, Bertrand, Sonnet, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699089/
https://www.ncbi.nlm.nih.gov/pubmed/36422591
http://dx.doi.org/10.3390/pathogens11111339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699089/
https://www.ncbi.nlm.nih.gov/pubmed/36422591
http://dx.doi.org/10.3390/pathogens11111339

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