Design, Synthesis, and Antiprotozoal Evaluation of New Promising 2,9-Bis[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline Derivatives, a Potential Alternative Scaffold to Drug Efflux

A series of novel 2,9-bis[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline derivatives was designed, synthesized, and evaluated in vitro against three protozoan parasites (Plasmodium falciparum, Leishmania donovani and Trypanosoma brucei brucei). Pharmacological results showed antiprotozoal...

Descripción completa

Detalles Bibliográficos
Autores principales: Guillon, Jean, Cohen, Anita, Boudot, Clotilde, Monic, Sarah, Savrimoutou, Solène, Moreau, Stéphane, Albenque-Rubio, Sandra, Lafon-Schmaltz, Camille, Dassonville-Klimpt, Alexandra, Mergny, Jean-Louis, Ronga, Luisa, Bernabeu de Maria, Mikel, Lamarche, Jeremy, Lago, Cristina Dal, Largy, Eric, Gabelica, Valérie, Moukha, Serge, Dozolme, Pascale, Agnamey, Patrice, Azas, Nadine, Mullié, Catherine, Courtioux, Bertrand, Sonnet, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699089/
https://www.ncbi.nlm.nih.gov/pubmed/36422591
http://dx.doi.org/10.3390/pathogens11111339

Ejemplares similares

Ejemplares similares