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Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis
The phytochemical study of Wisteria sinensis (Sims) DC. (Fabaceae), commonly known as the Chinese Wisteria, led to the isolation of seven oleanane-type glycosides from an aqueous-ethanolic extract of the roots. Among the seven isolated saponins, two have never been reported before: 3-O-α-L-rhamnopyr...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699193/ https://www.ncbi.nlm.nih.gov/pubmed/36431968 http://dx.doi.org/10.3390/molecules27227866 |
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author | Hobloss, Samir Bruguière, Antoine Pertuit, David Miyamoto, Tomofumi Tanaka, Chiaki Belloir, Christine Lacaille-Dubois, Marie-Aleth Briand, Loïc Mitaine-Offer, Anne-Claire |
author_facet | Hobloss, Samir Bruguière, Antoine Pertuit, David Miyamoto, Tomofumi Tanaka, Chiaki Belloir, Christine Lacaille-Dubois, Marie-Aleth Briand, Loïc Mitaine-Offer, Anne-Claire |
author_sort | Hobloss, Samir |
collection | PubMed |
description | The phytochemical study of Wisteria sinensis (Sims) DC. (Fabaceae), commonly known as the Chinese Wisteria, led to the isolation of seven oleanane-type glycosides from an aqueous-ethanolic extract of the roots. Among the seven isolated saponins, two have never been reported before: 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranosyl-22-O-acetylolean-12-ene-3β,16β,22β,30-tetrol, and 3-O-β-D-xylopyranosyl-(1→2)-β-D-glucuronopyranosylwistariasapogenol A. Based on the close structures between the saponins from W. sinensis, and the glycyrrhizin from licorice, the stimulation of the sweet taste receptor TAS1R2/TAS1R3 by these glycosides was evaluated. |
format | Online Article Text |
id | pubmed-9699193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96991932022-11-26 Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis Hobloss, Samir Bruguière, Antoine Pertuit, David Miyamoto, Tomofumi Tanaka, Chiaki Belloir, Christine Lacaille-Dubois, Marie-Aleth Briand, Loïc Mitaine-Offer, Anne-Claire Molecules Article The phytochemical study of Wisteria sinensis (Sims) DC. (Fabaceae), commonly known as the Chinese Wisteria, led to the isolation of seven oleanane-type glycosides from an aqueous-ethanolic extract of the roots. Among the seven isolated saponins, two have never been reported before: 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranosyl-22-O-acetylolean-12-ene-3β,16β,22β,30-tetrol, and 3-O-β-D-xylopyranosyl-(1→2)-β-D-glucuronopyranosylwistariasapogenol A. Based on the close structures between the saponins from W. sinensis, and the glycyrrhizin from licorice, the stimulation of the sweet taste receptor TAS1R2/TAS1R3 by these glycosides was evaluated. MDPI 2022-11-15 /pmc/articles/PMC9699193/ /pubmed/36431968 http://dx.doi.org/10.3390/molecules27227866 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hobloss, Samir Bruguière, Antoine Pertuit, David Miyamoto, Tomofumi Tanaka, Chiaki Belloir, Christine Lacaille-Dubois, Marie-Aleth Briand, Loïc Mitaine-Offer, Anne-Claire Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis |
title | Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis |
title_full | Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis |
title_fullStr | Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis |
title_full_unstemmed | Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis |
title_short | Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis |
title_sort | activation of a sweet taste receptor by oleanane-type glycosides from wisteria sinensis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699193/ https://www.ncbi.nlm.nih.gov/pubmed/36431968 http://dx.doi.org/10.3390/molecules27227866 |
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