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Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis

The phytochemical study of Wisteria sinensis (Sims) DC. (Fabaceae), commonly known as the Chinese Wisteria, led to the isolation of seven oleanane-type glycosides from an aqueous-ethanolic extract of the roots. Among the seven isolated saponins, two have never been reported before: 3-O-α-L-rhamnopyr...

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Autores principales: Hobloss, Samir, Bruguière, Antoine, Pertuit, David, Miyamoto, Tomofumi, Tanaka, Chiaki, Belloir, Christine, Lacaille-Dubois, Marie-Aleth, Briand, Loïc, Mitaine-Offer, Anne-Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699193/
https://www.ncbi.nlm.nih.gov/pubmed/36431968
http://dx.doi.org/10.3390/molecules27227866
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author Hobloss, Samir
Bruguière, Antoine
Pertuit, David
Miyamoto, Tomofumi
Tanaka, Chiaki
Belloir, Christine
Lacaille-Dubois, Marie-Aleth
Briand, Loïc
Mitaine-Offer, Anne-Claire
author_facet Hobloss, Samir
Bruguière, Antoine
Pertuit, David
Miyamoto, Tomofumi
Tanaka, Chiaki
Belloir, Christine
Lacaille-Dubois, Marie-Aleth
Briand, Loïc
Mitaine-Offer, Anne-Claire
author_sort Hobloss, Samir
collection PubMed
description The phytochemical study of Wisteria sinensis (Sims) DC. (Fabaceae), commonly known as the Chinese Wisteria, led to the isolation of seven oleanane-type glycosides from an aqueous-ethanolic extract of the roots. Among the seven isolated saponins, two have never been reported before: 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranosyl-22-O-acetylolean-12-ene-3β,16β,22β,30-tetrol, and 3-O-β-D-xylopyranosyl-(1→2)-β-D-glucuronopyranosylwistariasapogenol A. Based on the close structures between the saponins from W. sinensis, and the glycyrrhizin from licorice, the stimulation of the sweet taste receptor TAS1R2/TAS1R3 by these glycosides was evaluated.
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spelling pubmed-96991932022-11-26 Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis Hobloss, Samir Bruguière, Antoine Pertuit, David Miyamoto, Tomofumi Tanaka, Chiaki Belloir, Christine Lacaille-Dubois, Marie-Aleth Briand, Loïc Mitaine-Offer, Anne-Claire Molecules Article The phytochemical study of Wisteria sinensis (Sims) DC. (Fabaceae), commonly known as the Chinese Wisteria, led to the isolation of seven oleanane-type glycosides from an aqueous-ethanolic extract of the roots. Among the seven isolated saponins, two have never been reported before: 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranosyl-22-O-acetylolean-12-ene-3β,16β,22β,30-tetrol, and 3-O-β-D-xylopyranosyl-(1→2)-β-D-glucuronopyranosylwistariasapogenol A. Based on the close structures between the saponins from W. sinensis, and the glycyrrhizin from licorice, the stimulation of the sweet taste receptor TAS1R2/TAS1R3 by these glycosides was evaluated. MDPI 2022-11-15 /pmc/articles/PMC9699193/ /pubmed/36431968 http://dx.doi.org/10.3390/molecules27227866 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hobloss, Samir
Bruguière, Antoine
Pertuit, David
Miyamoto, Tomofumi
Tanaka, Chiaki
Belloir, Christine
Lacaille-Dubois, Marie-Aleth
Briand, Loïc
Mitaine-Offer, Anne-Claire
Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis
title Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis
title_full Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis
title_fullStr Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis
title_full_unstemmed Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis
title_short Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis
title_sort activation of a sweet taste receptor by oleanane-type glycosides from wisteria sinensis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699193/
https://www.ncbi.nlm.nih.gov/pubmed/36431968
http://dx.doi.org/10.3390/molecules27227866
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