Regulation of Hepatocyte Nuclear Factor 4α Attenuated Lipotoxicity but Increased Bile Acid Toxicity in Non-Alcoholic Fatty Liver Disease

SIMPLE SUMMARY: Hepatic HNF4α inhibition can attenuate bile acid toxicity in NAFLD. However, it can aggravate hepatic steatosis, so it is necessary to study the optimal timing of HNF4α inhibition and the development of surrogate markers that can predict it. It is known that bile acid–induced toxicit...

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Detalles Bibliográficos
Autores principales: Roh, Yoon Jin, Kim, Yun, Lee, Jae Sun, Oh, Ju Hee, Lee, Seung Min, Yoon, Eileen Laurel, Lee, Sung Ryol, Jun, Dae Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699296/
https://www.ncbi.nlm.nih.gov/pubmed/36362837
http://dx.doi.org/10.3390/life12111682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699296/
https://www.ncbi.nlm.nih.gov/pubmed/36362837
http://dx.doi.org/10.3390/life12111682

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