Exploring the Inhibition of Quercetin on Acetylcholinesterase by Multispectroscopic and In Silico Approaches and Evaluation of Its Neuroprotective Effects on PC12 Cells

This study investigated the inhibitory mechanism of quercetin in acetylcholinesterase (AChE) and its neuroprotective effects on β-amyloid(25–35)-induced oxidative stress injury in PC12 cells. Quercetin inhibited AChE in a reversible mixed manner with an IC(50) of 4.59 ± 0.27 µM. The binding constant...

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Detalles Bibliográficos
Autores principales: Liao, Yijing, Mai, Xi, Wu, Xiaqing, Hu, Xing, Luo, Xiaoqiao, Zhang, Guowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699400/
https://www.ncbi.nlm.nih.gov/pubmed/36432070
http://dx.doi.org/10.3390/molecules27227971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699400/
https://www.ncbi.nlm.nih.gov/pubmed/36432070
http://dx.doi.org/10.3390/molecules27227971

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