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XLID syndrome gene Med12 promotes Ig isotype switching through chromatin modification and enhancer RNA regulation
The transcriptional coactivator Med12 regulates gene expression through its kinase module. Here, we show a kinase module–independent function of Med12 in CSR. Med12 is essential for super-enhancer activation by collaborating with p300-Jmjd6/Carm1 coactivator complexes. Med12 loss decreases H3K27 ace...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699684/ https://www.ncbi.nlm.nih.gov/pubmed/36427307 http://dx.doi.org/10.1126/sciadv.add1466 |