Cargando…
Sublytic gasdermin-D pores captured in atomistic molecular simulations
Gasdermin-D (GSDMD) is the ultimate effector of pyroptosis, a form of programmed cell death associated with pathogen invasion and inflammation. After proteolytic cleavage by caspases, the GSDMD N-terminal domain (GSDMD(NT)) assembles on the inner leaflet of the plasma membrane and induces the format...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699695/ https://www.ncbi.nlm.nih.gov/pubmed/36374182 http://dx.doi.org/10.7554/eLife.81432 |