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Sublytic gasdermin-D pores captured in atomistic molecular simulations

Gasdermin-D (GSDMD) is the ultimate effector of pyroptosis, a form of programmed cell death associated with pathogen invasion and inflammation. After proteolytic cleavage by caspases, the GSDMD N-terminal domain (GSDMD(NT)) assembles on the inner leaflet of the plasma membrane and induces the format...

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Detalles Bibliográficos
Autores principales:	Schaefer, Stefan L, Hummer, Gerhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699695/ https://www.ncbi.nlm.nih.gov/pubmed/36374182 http://dx.doi.org/10.7554/eLife.81432

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