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ESR1 dysfunction triggers neuroinflammation as a critical upstream causative factor of the Alzheimer’s disease process

Alzheimer's disease (AD) accounts for approximately 60% of dementia cases worldwide. Advanced age is the most significant risk factor for AD and approximately two-thirds of cases relate to women. While the previous meta-analysis suggests that estrogen receptor (ESR) genetic polymorphisms are cl...

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Detalles Bibliográficos
Autores principales: Liu, Junying, Yuan, Shouli, Niu, Xinhui, Kelleher, Robbie, Sheridan, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699767/
https://www.ncbi.nlm.nih.gov/pubmed/36326669
http://dx.doi.org/10.18632/aging.204359