Cargando…

Spike Protein Subunits of SARS-CoV-2 Alter Mitochondrial Metabolism in Human Pulmonary Microvascular Endothelial Cells: Involvement of Factor Xa

BACKGROUND: Mitochondria have been involved in host defense upon viral infections. Factor Xa (FXa), a coagulating factor, may also have influence on mitochondrial functionalities. The aim was to analyze if in human pulmonary microvascular endothelial cells (HPMEC), the SARS-CoV-2 (COVID-19) spike pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zekri-Nechar, Khaoula, Zamorano-León, José J., Reche, Carmen, Giner, Manel, López-de-Andrés, Ana, Jiménez-García, Rodrigo, López-Farré, Antonio J., Martínez-Martínez, Carlos Hugo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699787/ https://www.ncbi.nlm.nih.gov/pubmed/36438904 http://dx.doi.org/10.1155/2022/1118195

Ejemplares similares

Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose
por: Zekri-Nechar, Khaoula, et al.
Publicado: (2022)

Mitochondrial mitophagy protection combining rivaroxaban and aspirin in high glucose-exposed human coronary artery endothelial cell. An in vitro study
por: Zekri-Nechar, Khaoula, et al.
Publicado: (2022)

Analysis of Prior Aspirin Treatment on in-Hospital Outcome of Geriatric COVID-19 Infected Patients
por: Zekri-Nechar, Khaoula, et al.
Publicado: (2022)

Low Levels of Influenza Vaccine Uptake among the Diabetic Population in Spain: A Time Trend Study from 2011 to 2020
por: Zamorano-Leon, Jose J., et al.
Publicado: (2021)

Effect of Pectin on the Expression of Proteins Associated with Mitochondrial Biogenesis and Cell Senescence in HT29-Human Colorectal Adenocarcinoma Cells
por: Zamorano-León, José Javier, et al.
Publicado: (2019)

Less Is More: Microvascular Thrombophylaxis With Factor-Xa Inhibitor Monotherapy
por: Kotha, Vikas S., et al.
Publicado: (2019)

Cleavage of spike protein of SARS coronavirus by protease factor Xa is associated with viral infectivity
por: Du, Lanying, et al.
Publicado: (2007)

HSP90 Inhibitors Modulate SARS-CoV-2 Spike Protein Subunit 1-Induced Human Pulmonary Microvascular Endothelial Activation and Barrier Dysfunction
por: Colunga Biancatelli, Ruben Manuel Luciano, et al.
Publicado: (2022)

Effects of the factor Xa inhibitor rivaroxaban on the differentiation of endothelial progenitor cells
por: Sohma, Ryoichi, et al.
Publicado: (2023)

Endothelial damage in major depression patients is modulated by SSRI treatment, as demonstrated by circulating biomarkers and an in vitro cell model
por: Lopez-Vilchez, I, et al.
Publicado: (2016)

An XA21-Associated Kinase (OsSERK2) Regulates Immunity Mediated by the XA21 and XA3 Immune Receptors
por: Chen, Xuewei, et al.
Publicado: (2014)

Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation
por: Arce, Maximiliano, et al.
Publicado: (2019)

Xa tantlin lisantiago /
por: Ibarra, José Xochihua
Publicado: (1993)

Coagulation Factor Xa
por: Brown, Mark A., et al.
Publicado: (2013)

Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection
por: Dong, Wenjuan, et al.
Publicado: (2023)

Endothelial ILK induces cardioprotection by preventing coronary microvascular dysfunction and endothelial-to-mesenchymal transition
por: Reventun, P., et al.
Publicado: (2023)

Cellular processing of bovine factors X and Xa by cultured bovine aortic endothelial cells
Publicado: (1985)

An experiment with VM/XA share
por: Pope, B G
Publicado: (1990)

Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors
por: Verhoef, Daniël, et al.
Publicado: (2017)

Trends and Predictors for the Uptake of Colon Cancer Screening Using the Fecal Occult Blood Test in Spain from 2011 to 2017
por: Zamorano-Leon, José Javier, et al.
Publicado: (2020)

Marker-aided Incorporation of Xa38, a Novel Bacterial Blight Resistance Gene, in PB1121 and Comparison of its Resistance Spectrum with xa13 + Xa21
por: Ellur, Ranjith K., et al.
Publicado: (2016)

Measuring residual anti‐Xa activity of direct factor Xa inhibitors after reversal with andexanet alfa
por: Bourdin, Matthieu, et al.
Publicado: (2021)

Gender Differences in the Prevalence of Mental Health, Psychological Distress and Psychotropic Medication Consumption in Spain: A Nationwide Population-Based Study
por: Maestre-Miquel, Clara, et al.
Publicado: (2021)

Trends in incidence of proximal humerus fractures, surgical procedures and outcomes among elderly hospitalized patients with and without type 2 diabetes in Spain (2001–2013)
por: Martinez-Huedo, Maria Angeles, et al.
Publicado: (2017)

Litlin xa ninin = Alabanzas para todos los santos /
Publicado: (1993)

Increased Microparticle Production and Impaired Microvascular Endothelial Function in Aldosterone-Salt-Treated Rats: Protective Effects of Polyphenols
por: López Andrés, Natalia, et al.
Publicado: (2012)

Microvascular and Endothelial Dysfunction in Prediabetes
por: Lamprou, Stamatina, et al.
Publicado: (2023)

The new factor Xa inhibitor: Apixaban
por: Bhanwra, Sangeeta, et al.
Publicado: (2014)

Clinical Scenarios for Discordant Anti-Xa
por: Vera-Aguilera, Jesus, et al.
Publicado: (2016)

Roles of factor Xa beyond coagulation
por: Ruf, Wolfram
Publicado: (2021)

Influence of dietary intervention on microvascular endothelial function in coronary patients and atherothrombotic risk of recurrence
por: Millan-Orge, Marta, et al.
Publicado: (2021)

Silencing of the Rice Gene LRR1 Compromises Rice Xa21 Transcript Accumulation and XA21-Mediated Immunity
por: Caddell, Daniel F., et al.
Publicado: (2017)

Effectiveness of 3 Polyherbal Formulations (EcXaPu, EcXa, and EcPu) on the Management of Oxidative Stress and Hyperglycemia
por: Essola, Nadine Ndoe, et al.
Publicado: (2022)

SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation
por: Perico, Luca, et al.
Publicado: (2022)

Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome
por: Artim-Esen, Bahar, et al.
Publicado: (2017)

Experiences with VM/XA minidisk caching at CERN
por: Pope, B G
Publicado: (1990)

Pharmacodynamics and Pharmacokinetics of oral factor Xa inhibitors
por: Persson, Pontus B
Publicado: (2015)

Microvascular endothelial cells of the corpus luteum
por: Davis, John S, et al.
Publicado: (2003)

Sepsis and Intestinal Microvascular Endothelial Dysfunction
por: Chen, De-Chang
Publicado: (2017)

Ortholog Alleles at Xa3/Xa26 Locus Confer Conserved Race-Specific Resistance against Xanthomonas oryzae in Rice
por: Li, Hong-Jing, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_dcdsbad6t5oedl2l795al18af8