PUM1 mediates the posttranscriptional regulation of human fetal hemoglobin

The fetal-to-adult hemoglobin switching at about the time of birth involves a shift in expression from γ-globin to β-globin in erythroid cells. Effective re-expression of fetal γ-globin can ameliorate sickle cell anemia and β-thalassemia. Despite the physiological and clinical relevance of this swit...

Descripción completa

Detalles Bibliográficos
Autores principales: Elagooz, Reem, Dhara, Anita R., Gott, Rose M., Adams, Sarah E., White, Rachael A., Ghosh, Arnab, Ganguly, Shinjini, Man, Yuncheng, Owusu-Ansah, Amma, Mian, Omar Y., Gurkan, Umut A., Komar, Anton A., Ramamoorthy, Mahesh, Gnanapragasam, Merlin Nithya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699939/
https://www.ncbi.nlm.nih.gov/pubmed/35667093
http://dx.doi.org/10.1182/bloodadvances.2021006730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699939/
https://www.ncbi.nlm.nih.gov/pubmed/35667093
http://dx.doi.org/10.1182/bloodadvances.2021006730

Ejemplares similares