Cargando…

PUM1 mediates the posttranscriptional regulation of human fetal hemoglobin

The fetal-to-adult hemoglobin switching at about the time of birth involves a shift in expression from γ-globin to β-globin in erythroid cells. Effective re-expression of fetal γ-globin can ameliorate sickle cell anemia and β-thalassemia. Despite the physiological and clinical relevance of this swit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elagooz, Reem, Dhara, Anita R., Gott, Rose M., Adams, Sarah E., White, Rachael A., Ghosh, Arnab, Ganguly, Shinjini, Man, Yuncheng, Owusu-Ansah, Amma, Mian, Omar Y., Gurkan, Umut A., Komar, Anton A., Ramamoorthy, Mahesh, Gnanapragasam, Merlin Nithya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2022
Materias:	Stimulus Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699939/ https://www.ncbi.nlm.nih.gov/pubmed/35667093 http://dx.doi.org/10.1182/bloodadvances.2021006730

Ejemplares similares

Gata2 +9.5 enhancer regulates adult hematopoietic stem cell self-renewal and T-cell development
por: You, Xiaona, et al.
Publicado: (2022)

Real-world use of tisagenlecleucel in infant acute lymphoblastic leukemia
por: Moskop, Amy, et al.
Publicado: (2022)

Dissecting platelet proteomics to understand the pathophysiology of immune thrombocytopenia: studies in mouse models
por: Martínez-Botía, Patricia, et al.
Publicado: (2022)

Novel insights into mouse models of ectopic proplatelet release
por: Spindler, Markus, et al.
Publicado: (2022)

Haptoglobin 1 allele predicts higher serum haptoglobin concentration and lower multiorgan failure risk in sickle cell disease
por: Ruiz, Maria A., et al.
Publicado: (2022)

Blood transfusion trends in the United States: national inpatient sample, 2015 to 2018
por: Goel, Ruchika, et al.
Publicado: (2021)

Treatment-free remission after ceasing venetoclax-based therapy in patients with acute myeloid leukemia
por: Chua, Chong Chyn, et al.
Publicado: (2022)

Physiologically based serum ferritin thresholds for iron deficiency in women of reproductive age who are blood donors
por: Addo, O. Yaw, et al.
Publicado: (2022)

Safety and efficacy of tisagenlecleucel plus pembrolizumab in patients with r/r DLBCL: phase 1b PORTIA study results
por: Jaeger, Ulrich, et al.
Publicado: (2022)

Convalescent plasma with a high level of virus-specific antibody effectively neutralizes SARS-CoV-2 variants of concern
por: Li, Maggie, et al.
Publicado: (2022)

VpreB surrogate light chain expression in B-lineage ALL: a report from the Children’s Oncology Group
por: Winter, Stuart S., et al.
Publicado: (2022)

Origins of bloodstream infections following fecal microbiota transplantation: a strain-level analysis
por: Eshel, Adi, et al.
Publicado: (2022)

Neutrophil cathepsin G proteolysis of protease-activated receptor 4 generates a novel, functional tethered ligand
por: Stoller, Michelle L., et al.
Publicado: (2022)

Associating drug sensitivity with differentiation status identifies effective combinations for acute myeloid leukemia
por: Kurtz, Stephen E., et al.
Publicado: (2022)

Single-cell polyfunctional proteomics of CD4 cells from patients with AML predicts responses to anti–PD-1–based therapy
por: Abbas, Hussein A., et al.
Publicado: (2021)

Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance
por: Doherty, Dearbhla, et al.
Publicado: (2022)

Identification of novel γ-globin inducers among all potential erythroid druggable targets
por: Yu, Lei, et al.
Publicado: (2022)

Single-cell sequencing demonstrates complex resistance landscape in CLL and MCL treated with BTK and BCL2 inhibitors
por: Thompson, Ella R., et al.
Publicado: (2022)

Prevalence of heavy chain MGUS by race and family history risk groups using a high-sensitivity screening method
por: Vachon, Celine M., et al.
Publicado: (2022)

Outcomes of patients with CLL sequentially resistant to both BCL2 and BTK inhibition
por: Lew, Thomas E., et al.
Publicado: (2021)

Transformation of FL into DLBCL with a PMBL gene expression signature
por: Loveday, Tristan, et al.
Publicado: (2022)

Validation and clinical application of transactivation assays for RUNX1 variant classification
por: Decker, Melanie, et al.
Publicado: (2022)

Day 30 SUV(max) predicts progression in patients with lymphoma achieving PR/SD after CAR T-cell therapy
por: Al Zaki, Ajlan, et al.
Publicado: (2022)

Genetic features and clinical outcomes of patients with isolated and comutated DDX41-mutated myeloid neoplasms
por: Alkhateeb, Hassan B., et al.
Publicado: (2022)

Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies
por: Saygin, Caner, et al.
Publicado: (2022)

Clinical impact of NPM1-mutant molecular persistence after chemotherapy for acute myeloid leukemia
por: Tiong, Ing S., et al.
Publicado: (2021)

Role of stem cell transplant in CD30(+) PTCL following frontline brentuximab vedotin plus CHP or CHOP in ECHELON-2
por: Savage, Kerry J., et al.
Publicado: (2022)

CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes
por: Huang, Benjamin J., et al.
Publicado: (2021)

A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas
por: Munshi, Manit, et al.
Publicado: (2022)

COVID-19 and CAR T cells: a report on current challenges and future directions from the EPICOVIDEHA survey by EHA-IDWP
por: Busca, Alessandro, et al.
Publicado: (2022)

Clinical care pathway for the evaluation of patients with suspected VITT after ChAdOx1 nCoV-19 vaccination
por: Lee, Agnes Y. Y., et al.
Publicado: (2022)

Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation
por: Shahin, Tala, et al.
Publicado: (2022)

Dissemination of extreme levels of extracellular vesicles: tissue factor activity in patients with severe COVID-19
por: Guervilly, Christophe, et al.
Publicado: (2021)

The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A
por: Wu, Shang-Chuen, et al.
Publicado: (2021)

Impact of sickle cell trait on morbidity and mortality from SARS-CoV-2 infection
por: Merz, Lauren E., et al.
Publicado: (2021)

IL-6 antagonists to replace systemic corticosteroids as the preferred anti-inflammatory therapy in patients with COVID-19?
por: Kow, Chia Siang, et al.
Publicado: (2022)

A novel class of ZNF384 aberrations in acute leukemia
por: Zaliova, Marketa, et al.
Publicado: (2021)

Anti-cysteine/spacer antibodies that open ADAMTS13 are a common feature in iTTP
por: De Waele, Laure, et al.
Publicado: (2021)

Rational biomarker development for the early and minimally invasive monitoring of AML
por: Abdelhamed, Sherif, et al.
Publicado: (2021)

TET2 mutations as a part of DNA dioxygenase deficiency in myelodysplastic syndromes
por: Gurnari, Carmelo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lnv5qs8ccfhpuv7jpdo3hdsq7u