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Intracellular pathogen Leishmania intervenes in iron loading into ferritin by cleaving chaperones in host macrophages as an iron acquisition strategy

Iron (Fe) sequestration is one of the most important strategies of the host to control the growth and survival of invading pathogens. Ferritin (Ft) plays a pivotal role in the sequestration mechanism of mammalian hosts by storing Fe. Recent evidence suggests that poly(rC)-binding proteins (PCBPs) ac...

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Detalles Bibliográficos
Autores principales: Sen, Sandhya, Bal, Saswat Kumar, Yadav, Sameeksha, Mishra, Pragya, G, Vishnu Vivek, Rastogi, Ruchir, Mukhopadhyay, Chinmay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700016/
https://www.ncbi.nlm.nih.gov/pubmed/36309090
http://dx.doi.org/10.1016/j.jbc.2022.102646