The kringle IV type 2 domain variant 4925G>A causes the elusive association signal of the LPA pentanucleotide repeat

Lipoprotein(a) [Lp(a)] concentrations are regulated by the LPA gene mainly via the large kringle IV-type 2 (KIV-2) copy number variation and multiple causal variants. Early studies suggested an effect of long pentanucleotide repeat (PNR) alleles (10 and 11 repeats, PNR10 and PNR11) in the LPA promot...

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Detalles Bibliográficos
Autores principales: Grüneis, Rebecca, Weissensteiner, Hansi, Lamina, Claudia, Schönherr, Sebastian, Forer, Lukas, Di Maio, Silvia, Streiter, Gertraud, Peters, Annette, Gieger, Christian, Kronenberg, Florian, Coassin, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700027/
https://www.ncbi.nlm.nih.gov/pubmed/36309064
http://dx.doi.org/10.1016/j.jlr.2022.100306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700027/
https://www.ncbi.nlm.nih.gov/pubmed/36309064
http://dx.doi.org/10.1016/j.jlr.2022.100306

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