Cargando…

Siponimod exerts neuroprotective effects on the retina and higher visual pathway through neuronal S1PR1 in experimental glaucoma

Sphingosine-1-phosphate receptor (S1PR) signaling regulates diverse pathophysiological processes in the central nervous system. The role of S1PR signaling in neurodegenerative conditions is still largely unidentified. Siponimod is a specific modulator of S1P1 and S1P5 receptors, an immunosuppressant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Basavarajappa, Devaraj, Gupta, Vivek, Chitranshi, Nitin, Wall, Roshana Vander, Rajput, Rashi, Pushpitha, Kanishka, Sharma, Samridhi, Mirzaei, Mehdi, Klistorner, Alexander, Graham, Stuart L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700103/ https://www.ncbi.nlm.nih.gov/pubmed/36204852 http://dx.doi.org/10.4103/1673-5374.344952

Ejemplares similares

Anti-inflammatory Effects of Siponimod in a Mouse Model of Excitotoxicity-Induced Retinal Injury
por: Basavarajappa, Devaraj, et al.
Publicado: (2023)

Neuroserpin, a crucial regulator for axogenesis, synaptic modelling and cell–cell interactions in the pathophysiology of neurological disease
por: Godinez, Angela, et al.
Publicado: (2022)

Evolving geographic diversity in SARS-CoV2 and in silico analysis of replicating enzyme 3CL(pro) targeting repurposed drug candidates
por: Chitranshi, Nitin, et al.
Publicado: (2020)

Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions
por: Palanivel, Viswanthram, et al.
Publicado: (2022)

Inner retinal injury in experimental glaucoma is prevented upon AAV mediated Shp2 silencing in a caveolin dependent manner
por: Abbasi, Mojdeh, et al.
Publicado: (2021)

Fingolimod effects on the brain are mediated through biochemical modulation of bioenergetics, autophagy, and neuroinflammatory networks
por: Mirzaei, Mehdi, et al.
Publicado: (2022)

Correction to: Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement
por: Sharma, Samridhi, et al.
Publicado: (2022)

Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement
por: Sharma, Samridhi, et al.
Publicado: (2022)

Mechanism of Siponimod: Anti-Inflammatory and Neuroprotective Mode of Action
por: Behrangi, Newshan, et al.
Publicado: (2019)

Molecular determinants and interaction data of cyclic peptide inhibitor with the extracellular domain of TrkB receptor
por: Chitranshi, Nitin, et al.
Publicado: (2016)

Does Siponimod Exert Direct Effects in the Central Nervous System?
por: Kipp, Markus
Publicado: (2020)

Amyloid β Induces Early Changes in the Ribosomal Machinery, Cytoskeletal Organization and Oxidative Phosphorylation in Retinal Photoreceptor Cells
por: Deng, Liting, et al.
Publicado: (2019)

The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures
por: O’Sullivan, Catherine, et al.
Publicado: (2016)

Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin
por: Gupta, Vivek, et al.
Publicado: (2017)

Oxidative Stress Induced Dysfunction of Protein Synthesis in 661W Mice Photoreceptor Cells
por: Deng, Liting, et al.
Publicado: (2023)

Siponimod for multiple sclerosis
Publicado: (2021)

Siponimod ameliorates experimental autoimmune neuritis
por: Uchi, Takafumi, et al.
Publicado: (2023)

Regulation of Brain-Derived Neurotrophic Factor and Growth Factor Signaling Pathways by Tyrosine Phosphatase Shp2 in the Retina: A Brief Review
por: Abbasi, Mojdeh, et al.
Publicado: (2018)

Migraine, interferon β1a and siponimod immunomodulator therapies
por: Dahaba, Ashraf A., et al.
Publicado: (2022)

Prospects of siponimod in secondary progressive multiple sclerosis
por: McGinley, Marisa, et al.
Publicado: (2018)

Siponimod: A Review in Secondary Progressive Multiple Sclerosis
por: Scott, Lesley J.
Publicado: (2020)

Assessment of neuroprotection in the retina with DARC
por: Guo, Li, et al.
Publicado: (2008)

Neuroprotective Effects of Lutein in the Retina
por: Ozawa, Yoko, et al.
Publicado: (2012)

Correction to: Siponimod: A Review in Secondary Progressive Multiple Sclerosis
por: Scott, Lesley J.
Publicado: (2021)

Siponimod: Disentangling disability and relapses in secondary progressive multiple sclerosis
por: Cree, Bruce AC, et al.
Publicado: (2020)

Siponimod Modulates the Reaction of Microglial Cells to Pro-Inflammatory Stimulation
por: Gruchot, Joel, et al.
Publicado: (2022)

Siponimod ameliorates metabolic oligodendrocyte injury via the sphingosine-1 phosphate receptor 5
por: Behrangi, Newshan, et al.
Publicado: (2022)

Neurodegeneration, Neuroprotection and Regeneration in the Zebrafish Retina
por: Stella, Salvatore L., et al.
Publicado: (2021)

The neuroprotective role of Wnt signaling in the retina
por: Kassumeh, Stefan, et al.
Publicado: (2021)

Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis
por: Gentile, Antonietta, et al.
Publicado: (2016)

Impact of siponimod on vaccination response in a randomized, placebo-controlled study
por: Ufer, Mike, et al.
Publicado: (2017)

COVID-19 Infection in Fingolimod- or Siponimod-Treated Patients: Case Series
por: Sullivan, Roseanne, et al.
Publicado: (2021)

Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models
por: Dietrich, Michael, et al.
Publicado: (2022)

The Two Sides of Siponimod: Evidence for Brain and Immune Mechanisms in Multiple Sclerosis
por: Cohan, Stanley L., et al.
Publicado: (2022)

Identification of Novel Cathepsin B Inhibitors with Implications in Alzheimer’s Disease: Computational Refining and Biochemical Evaluation
por: Chitranshi, Nitin, et al.
Publicado: (2021)

Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms
por: Xu, Zifen, et al.
Publicado: (2022)

Neuroprotection of the inner retina: Müller cells and lactate
por: Vohra, Rupali, et al.
Publicado: (2018)

Neuroprotective effects of quercetin in diabetic rat retina
por: Ola, Mohammad S., et al.
Publicado: (2017)

Neuroprotection, Neuroenhancement, and Neuroregeneration of the Retina and Optic Nerve
por: Johnson, Thomas V., et al.
Publicado: (2022)

Editorial: Neuroprotective mechanisms and translational approaches in the retina
por: Sahin, Afsun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5hujmth2paatt5clobvstlkl9d