OR12-2 Inhibition of Basal and ACTH-stimulated Cortisol Secretion in Humans Using an Oral Nonpeptide ACTH Antagonist (CRN04894)

CRN04894 is a potent orally bioavailable MC2R (adrenal cortex specific ACTH receptor) antagonist (Kb=0.34 nM) that is >1000-fold selective for MC2R over other melanocortin receptor subtypes. In rats receiving continuous administration of ACTH via subcutaneously implanted osmotic pumps, oral admin...

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Detalles Bibliográficos
Autores principales: Betz, Stephen, Ferrara-Cook, Christine, Hernandez-Illas, Martha, Luo, Rosa, Madan, Ajay, Miller, Stephanie, Struthers, Scott, Trainer, Peter, Wang, Yang, Krasner, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Adrenal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700278/
http://dx.doi.org/10.1210/jendso/bvac150.172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700278/
http://dx.doi.org/10.1210/jendso/bvac150.172

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