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Targeting fibroblast growth factor receptors causes severe craniofacial malformations in zebrafish larvae

BACKGROUND AND OBJECTIVE: A key pathway controlling skeletal development is fibroblast growth factor (FGF) and FGF receptor (FGFR) signaling. Major regulatory functions of FGF signaling are chondrogenesis, endochondral and intramembranous bone development. In this study we focus on fgfr2, as mutatio...

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Detalles Bibliográficos
Autores principales:	Gebuijs, Liesbeth, Wagener, Frank A., Zethof, Jan, Carels, Carine E., Von den Hoff, Johannes W., Metz, Juriaan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2022
Materias:	Aquaculture, Fisheries and Fish Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700454/ https://www.ncbi.nlm.nih.gov/pubmed/36444384 http://dx.doi.org/10.7717/peerj.14338

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