Endothelial Rbpj deletion normalizes Notch4-induced brain arteriovenous malformation in mice

Upregulation of Notch signaling is associated with brain arteriovenous malformation (bAVM), a disease that lacks pharmacological treatments. Tetracycline (tet)-regulatable endothelial expression of constitutively active Notch4 (Notch4*(tetEC)) from birth induced bAVMs in 100% of mice by P16. To test...

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Detalles Bibliográficos
Autores principales: Nielsen, Corinne M., Zhang, Xuetao, Raygor, Kunal, Wang, Shaoxun, Bollen, Andrew W., Wang, Rong A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700524/
https://www.ncbi.nlm.nih.gov/pubmed/36441145
http://dx.doi.org/10.1084/jem.20211390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700524/
https://www.ncbi.nlm.nih.gov/pubmed/36441145
http://dx.doi.org/10.1084/jem.20211390

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