MYC and MET cooperatively drive hepatocellular carcinoma with distinct molecular traits and vulnerabilities

Enhanced activation of the transcription factor MYC and of the receptor tyrosine kinase MET are among the events frequently occurring in hepatocellular carcinoma (HCC). Both genes individually act as drivers of liver cancer initiation and progression. However, their concomitant alteration in HCC has...

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Detalles Bibliográficos
Autores principales: Sequera, Celia, Grattarola, Margherita, Holczbauer, Agnes, Dono, Rosanna, Pizzimenti, Stefania, Barrera, Giuseppina, Wangensteen, Kirk J., Maina, Flavio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700715/
https://www.ncbi.nlm.nih.gov/pubmed/36433941
http://dx.doi.org/10.1038/s41419-022-05411-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700715/
https://www.ncbi.nlm.nih.gov/pubmed/36433941
http://dx.doi.org/10.1038/s41419-022-05411-6

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