Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine

TP53 nonsense mutations in cancer produce truncated inactive p53 protein. We show that 5-FU metabolite 5-Fluorouridine (FUr) induces full-length p53 in human tumor cells carrying R213X nonsense mutant TP53. Ribosome profiling visualized translational readthrough at the R213X premature stop codon and...

Descripción completa

Detalles Bibliográficos
Autores principales: Palomar-Siles, Mireia, Heldin, Angelos, Zhang, Meiqiongzi, Strandgren, Charlotte, Yurevych, Viktor, van Dinter, Jip T., Engels, Sem A. G., Hofman, Damon A., Öhlin, Susanne, Meineke, Birthe, Bykov, Vladimir J. N., van Heesch, Sebastiaan, Wiman, Klas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700717/
https://www.ncbi.nlm.nih.gov/pubmed/36433934
http://dx.doi.org/10.1038/s41419-022-05431-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700717/
https://www.ncbi.nlm.nih.gov/pubmed/36433934
http://dx.doi.org/10.1038/s41419-022-05431-2

Ejemplares similares