Cargando…

Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine

TP53 nonsense mutations in cancer produce truncated inactive p53 protein. We show that 5-FU metabolite 5-Fluorouridine (FUr) induces full-length p53 in human tumor cells carrying R213X nonsense mutant TP53. Ribosome profiling visualized translational readthrough at the R213X premature stop codon and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Palomar-Siles, Mireia, Heldin, Angelos, Zhang, Meiqiongzi, Strandgren, Charlotte, Yurevych, Viktor, van Dinter, Jip T., Engels, Sem A. G., Hofman, Damon A., Öhlin, Susanne, Meineke, Birthe, Bykov, Vladimir J. N., van Heesch, Sebastiaan, Wiman, Klas G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700717/ https://www.ncbi.nlm.nih.gov/pubmed/36433934 http://dx.doi.org/10.1038/s41419-022-05431-2

Ejemplares similares

Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene
por: Palomar-Siles, Mireia, et al.
Publicado: (2023)

Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN
por: Heldin, Angelos, et al.
Publicado: (2023)

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors
por: Zhang, Meiqiongzi, et al.
Publicado: (2018)

Nonaminoglycoside compounds induce readthrough of nonsense mutations
por: Du, Liutao, et al.
Publicado: (2009)

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy
por: Bykov, Vladimir J. N., et al.
Publicado: (2016)

Variable readthrough responsiveness of nonsense mutations in hemophilia A
por: Martorell, Lluis, et al.
Publicado: (2020)

Strategies against Nonsense: Oxadiazoles as Translational Readthrough-Inducing Drugs (TRIDs)
por: Campofelice, Ambra, et al.
Publicado: (2019)

Molecular Insights into Determinants of Translational Readthrough and Implications for Nonsense Suppression Approaches
por: Lombardi, Silvia, et al.
Publicado: (2020)

Functional Restoration of BRCA1 Nonsense Mutations by Aminoglycoside-Induced Readthrough
por: Abreu, Renata B. V., et al.
Publicado: (2022)

Synergy between Readthrough and Nonsense Mediated Decay Inhibition in a Murine Model of Cystic Fibrosis Nonsense Mutations
por: McHugh, Daniel R., et al.
Publicado: (2020)

Screening Readthrough Compounds to Suppress Nonsense Mutations: Possible Application to β-Thalassemia
por: Borgatti, Monica, et al.
Publicado: (2020)

Dbp5/DDX19 between Translational Readthrough and Nonsense Mediated Decay
por: Beißel, Christian, et al.
Publicado: (2020)

Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases
por: Guchhait, Sandip, et al.
Publicado: (2023)

A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay
por: Baker, Stacey L., et al.
Publicado: (2017)

Functional recovery of a novel knockin mouse model of dysferlinopathy by readthrough of nonsense mutation
por: Seo, Kyowon, et al.
Publicado: (2021)

2-Guanidino-quinazoline promotes the readthrough of nonsense mutations underlying human genetic diseases
por: Bidou, Laure, et al.
Publicado: (2022)

Evaluation of Novel Enhancer Compounds in Gentamicin-Mediated Readthrough of Nonsense Mutations in Rett Syndrome
por: Wong, Keit Men, et al.
Publicado: (2023)

Intergenic splicing-stimulated transcriptional readthrough is suppressed by nonsense-mediated mRNA decay in Arabidopsis
por: Kurihara, Yukio, et al.
Publicado: (2022)

Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model
por: Brendel, Cornelia, et al.
Publicado: (2010)

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
por: Sharma, Jyoti, et al.
Publicado: (2021)

Statistical Analysis of Readthrough Levels for Nonsense Mutations in Mammalian Cells Reveals a Major Determinant of Response to Gentamicin
por: Floquet, Célia, et al.
Publicado: (2012)

Erratum to: Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model
por: Brendel, Cornelia, et al.
Publicado: (2013)

Nonsense suppression induced readthrough of a novel PAX6 mutation in patient‐derived cells of congenital aniridia
por: Liu, Xiaoliang, et al.
Publicado: (2020)

Heterologous Stop Codon Readthrough of Metazoan Readthrough Candidates in Yeast
por: Chan, Clara S., et al.
Publicado: (2013)

Expression of the eRF1 translation termination factor is controlled by an autoregulatory circuit involving readthrough and nonsense-mediated decay in plants
por: Nyikó, Tünde, et al.
Publicado: (2017)

Readthrough of stop codons under limiting ABCE1 concentration involves frameshifting and inhibits nonsense-mediated mRNA decay
por: Annibaldis, Giuditta, et al.
Publicado: (2020)

NanoLuc reporters identify COL4A5 nonsense mutations susceptible to drug-induced stop codon readthrough
por: Omachi, Kohei, et al.
Publicado: (2022)

Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough
por: Lee, Rhianna E., et al.
Publicado: (2022)

Translational readthrough at F8 nonsense variants in the factor VIII B domain contributes to residual expression and lowers inhibitor association
por: Testa, Maria Francesca, et al.
Publicado: (2022)

Optimized 5-Fluorouridine Prodrug for Co-Loading with Doxorubicin in Clinically Relevant Liposomes
por: Wu, Debra, et al.
Publicado: (2021)

Downstream Alternate Start Site Allows N-Terminal Nonsense Variants to Escape NMD and Results in Functional Recovery by Readthrough and Modulator Combination
por: Bowling, Alyssa, et al.
Publicado: (2022)

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277
por: Zhang, Qiang, et al.
Publicado: (2018)

Correction: APR-246 reactivates mutant p53 by targeting cysteines 124 and 277
por: Zhang, Qiang, et al.
Publicado: (2019)

p53 as a hub in cellular redox regulation and therapeutic target in cancer
por: Eriksson, Sofi E, et al.
Publicado: (2019)

A Simple and Affordable Method to Create Nonsense Mutation Clones of p53 for Studying the Premature Termination Codon Readthrough Activity of PTC124
por: Chen, Chia-Chi, et al.
Publicado: (2023)

Amlexanox: Readthrough Induction and Nonsense-Mediated mRNA Decay Inhibition in a Charcot–Marie–Tooth Model of hiPSCs-Derived Neuronal Cells Harboring a Nonsense Mutation in GDAP1 Gene
por: Benslimane, Nesrine, et al.
Publicado: (2023)

Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor
por: Spenkuch, Felix, et al.
Publicado: (2014)

Enhanced Antitumor Effect of 5′‐Deoxy‐5‐fluorouridine by Oral Administration with l‐Cysteine
por: Iigo, Masaaki, et al.
Publicado: (1989)

Ribosomal frameshifting, jumping and readthrough
por: Weiss, Robert B.
Publicado: (1991)

Yeast applied readthrough inducing system (YARIS): an invivo assay for the comprehensive study of translational readthrough
por: Beznosková, Petra, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_md74v8b3pd2g6ods0vhibgnqet