mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity

Formation of branched organs requires sequential differentiation of stem cells. In this work, we find that the conducting airways derived from SOX2(+) progenitors in the murine lungs fail to form without mTOR complex 1 (mTORC1) signaling and are replaced by lung cysts. Proximal-distal patterning thr...

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Detalles Bibliográficos
Autores principales: Zhang, Kuan, Yao, Erica, Chuang, Ethan, Chen, Biao, Chuang, Evelyn Y., Chuang, Pao-Tien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700781/
https://www.ncbi.nlm.nih.gov/pubmed/36433959
http://dx.doi.org/10.1038/s41467-022-34763-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700781/
https://www.ncbi.nlm.nih.gov/pubmed/36433959
http://dx.doi.org/10.1038/s41467-022-34763-y

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