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mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity
Formation of branched organs requires sequential differentiation of stem cells. In this work, we find that the conducting airways derived from SOX2(+) progenitors in the murine lungs fail to form without mTOR complex 1 (mTORC1) signaling and are replaced by lung cysts. Proximal-distal patterning thr...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700781/ https://www.ncbi.nlm.nih.gov/pubmed/36433959 http://dx.doi.org/10.1038/s41467-022-34763-y |