Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity

Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical outcomes ranging from asymptomatic to severe disease and death. We previously reported reduced type I interferon in severe COVID-19 patients preceded clinical worsening. Further studies identified genetic mutat...

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Detalles Bibliográficos
Autores principales: Smith, Nikaïa, Possémé, Céline, Bondet, Vincent, Sugrue, Jamie, Townsend, Liam, Charbit, Bruno, Rouilly, Vincent, Saint-André, Violaine, Dott, Tom, Pozo, Andre Rodriguez, Yatim, Nader, Schwartz, Olivier, Cervantes-Gonzalez, Minerva, Ghosn, Jade, Bastard, Paul, Casanova, Jean Laurent, Szwebel, Tali-Anne, Terrier, Benjamin, Conlon, Niall, O’Farrelly, Cliona, Cheallaigh, Clíona Ní, Bourke, Nollaig M., Duffy, Darragh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700809/
https://www.ncbi.nlm.nih.gov/pubmed/36434007
http://dx.doi.org/10.1038/s41467-022-34895-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700809/
https://www.ncbi.nlm.nih.gov/pubmed/36434007
http://dx.doi.org/10.1038/s41467-022-34895-1

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