Interaction kinetics between p115-RhoGEF and Gα(13) are determined by unique molecular interactions affecting agonist sensitivity

The three RH-RhoGEFs (Guanine nucleotide exchange factors) p115-RhoGEF, LARG (leukemia-associated RhoGEF) and PDZ-RhoGEF link G-protein coupled receptors (GPCRs) with RhoA signaling through activation of Gα(12/13). In order to find functional differences in signaling between the different RH-RhoGEFs...

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Detalles Bibliográficos
Autores principales: Redlin, Fabian, Krett, Anna-Lena, Bünemann, Moritz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700851/
https://www.ncbi.nlm.nih.gov/pubmed/36434027
http://dx.doi.org/10.1038/s42003-022-04224-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700851/
https://www.ncbi.nlm.nih.gov/pubmed/36434027
http://dx.doi.org/10.1038/s42003-022-04224-9

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