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Interaction kinetics between p115-RhoGEF and Gα(13) are determined by unique molecular interactions affecting agonist sensitivity
The three RH-RhoGEFs (Guanine nucleotide exchange factors) p115-RhoGEF, LARG (leukemia-associated RhoGEF) and PDZ-RhoGEF link G-protein coupled receptors (GPCRs) with RhoA signaling through activation of Gα(12/13). In order to find functional differences in signaling between the different RH-RhoGEFs...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700851/ https://www.ncbi.nlm.nih.gov/pubmed/36434027 http://dx.doi.org/10.1038/s42003-022-04224-9 |