Cargando…

Noninvasive detection of pancreatic ductal adenocarcinoma using the methylation signature of circulating tumour DNA

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has the lowest overall survival rate primarily due to the late onset of symptoms and rapid progression. Reliable and accurate tests for early detection are lacking. We aimed to develop a noninvasive test for early PDAC detection by capturing the ci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Huanwen, Guo, Shiwei, Liu, Xiaoding, Li, Yatong, Su, Zhixi, He, Qiye, Liu, Xiaoqian, Zhang, Zhiwen, Yu, Lianyuan, Shi, Xiaohan, Gao, Suizhi, Wang, Huan, Pan, Yaqi, Ma, Chengcheng, Liu, Rui, Dai, Menghua, Jin, Gang, Liang, Zhiyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701032/ https://www.ncbi.nlm.nih.gov/pubmed/36434648 http://dx.doi.org/10.1186/s12916-022-02647-z

Ejemplares similares

Multi‐omics analysis of intra‐tumoural and inter‐tumoural heterogeneity in pancreatic ductal adenocarcinoma
por: Liu, Xiaoqian, et al.
Publicado: (2022)

DNA Methylation Haplotype Block Markers Efficiently Discriminate Follicular Thyroid Carcinoma from Follicular Adenoma
por: Zhang, Hui, et al.
Publicado: (2021)

Identification and Validation of Immune Molecular Subtypes in Pancreatic Ductal Adenocarcinoma: Implications for Prognosis and Immunotherapy
por: Li, Ruiyu, et al.
Publicado: (2021)

Upregulation of nucleoprotein AHNAK is associated with poor outcome of pancreatic ductal adenocarcinoma prognosis via mediating epithelial-mesenchymal transition
por: Zhang, Zhiwen, et al.
Publicado: (2019)

Nomogram for the Prediction of High-Grade Dysplasia and Invasive Carcinoma in Patients With Intraductal Papillary Mucinous Neoplasms of the Pancreas Based on Variables of Noninvasive Examination
por: Li, Bo, et al.
Publicado: (2021)

Comparison of 4- and 4 plus-courses S-1 administration as adjuvant chemotherapy for pancreatic ductal adenocarcinoma
por: Li, Bo, et al.
Publicado: (2021)

A neoadjuvant therapy compatible prognostic staging for resected pancreatic ductal adenocarcinoma
por: Zhu, Lingyu, et al.
Publicado: (2023)

Blood small extracellular vesicles derived miRNAs to differentiate pancreatic ductal adenocarcinoma from chronic pancreatitis
por: Guo, Shiwei, et al.
Publicado: (2021)

CD44+ Circulating Tumor Endothelial Cells Indicate Poor Prognosis in Pancreatic Ductal Adenocarcinoma After Radical Surgery: A Pilot Study
por: Xing, Cheng, et al.
Publicado: (2021)

RNA m(6)A Demethylase ALKBH5 Protects Against Pancreatic Ductal Adenocarcinoma via Targeting Regulators of Iron Metabolism
por: Huang, Rui, et al.
Publicado: (2021)

Preoperative detection of KRAS G12D mutation in ctDNA is a powerful predictor for early recurrence of resectable PDAC patients
por: Guo, Shiwei, et al.
Publicado: (2020)

Pros and Cons: High Proportion of Stromal Component Indicates Better Prognosis in Patients With Pancreatic Ductal Adenocarcinoma—A Research Based on the Evaluation of Whole-Mount Histological Slides
por: Li, Bo, et al.
Publicado: (2020)

PD-L1 in pancreatic ductal adenocarcinoma: a retrospective analysis of 373 Chinese patients using an in vitro diagnostic assay
por: Liang, Xiaolong, et al.
Publicado: (2018)

Expression of amphiregulin predicts poor outcome in patients with pancreatic ductal adenocarcinoma
por: Wang, Li, et al.
Publicado: (2016)

PSME3 Promotes TGFB1 Secretion by Pancreatic Cancer Cells to Induce Pancreatic Stellate Cell Proliferation
por: Yu, Lianyuan, et al.
Publicado: (2019)

Mutation profiles of follicular thyroid tumors by targeted sequencing
por: Duan, Huanli, et al.
Publicado: (2019)

Expression of signaling adaptor proteins predicts poor prognosis in pancreatic ductal adenocarcinoma
por: Wang, Lili, et al.
Publicado: (2017)

Portal Venous Circulating Tumor Cells Undergoing Epithelial-Mesenchymal Transition Exhibit Distinct Clinical Significance in Pancreatic Ductal Adenocarcinoma
por: Pan, Yujin, et al.
Publicado: (2021)

Relationship Between Radiomics and Risk of Lymph Node Metastasis in Pancreatic Ductal Adenocarcinoma
por: Bian, Yun, et al.
Publicado: (2019)

Radiomics nomogram for the preoperative prediction of lymph node metastasis in pancreatic ductal adenocarcinoma
por: Bian, Yun, et al.
Publicado: (2022)

Neutrophils assist the metastasis of circulating tumor cells in pancreatic ductal adenocarcinoma: A new hypothesis and a new predictor for distant metastasis
por: Tao, Lianyuan, et al.
Publicado: (2016)

Functional noninvasive detection of glycolytic pancreatic ductal adenocarcinoma
por: Heid, Irina, et al.
Publicado: (2022)

Next-Generation Sequencing Reveals a Very Low Prevalence of Deleterious Mutations of Homologous Recombination Repair Genes and Homologous Recombination Deficiency in Ovarian Clear Cell Carcinoma
por: Liu, Hangqi, et al.
Publicado: (2022)

Comparison of surgical treatments of tumor-induced osteomalacia in different locations in the lower limbs: A retrospective study
por: Li, Ye, et al.
Publicado: (2019)

Cross-platform comparisons for targeted bisulfite sequencing of MGISEQ-2000 and NovaSeq6000
por: Sun, Jin, et al.
Publicado: (2023)

Coexpression of EGFR and CXCR4 Predicts Poor Prognosis in Resected Pancreatic Ductal Adenocarcinoma
por: Wu, Huanwen, et al.
Publicado: (2015)

The Landscape of Genetic Alterations Stratified Prognosis in Oriental Pancreatic Cancer Patients
por: Guo, Shiwei, et al.
Publicado: (2021)

Circulating tumour cells as an indicator of early and systemic recurrence after surgical resection in pancreatic ductal adenocarcinoma
por: Park, Yejong, et al.
Publicado: (2021)

Next-generation sequencing revealed recurrent ZFPM1 mutations in encapsulated papillary carcinoma of the breast
por: Liu, Xuguang, et al.
Publicado: (2021)

Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma()
por: Kumar, Vidhya, et al.
Publicado: (2016)

G-CSF associates with neurogenesis and predicts prognosis and sensitivity to chemotherapy in pancreatic ductal adenocarcinoma
por: Zhang, Lingfu, et al.
Publicado: (2018)

Comparisons of different neoadjuvant chemotherapy regimens with or without stereotactic body radiation therapy for borderline resectable pancreatic cancer: study protocol of a prospective, randomized phase II trial (BRPCNCC-1)
por: Gao, Suizhi, et al.
Publicado: (2019)

Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing
por: Wang, Jing, et al.
Publicado: (2021)

Primary tumour–vessel tumour–nodal tumour classification for patients with invasive ductal carcinoma of the breast
por: Hasebe, T, et al.
Publicado: (2005)

Malignant and Noninvasive Skin Tumours in Renal Transplant Recipients
por: Roche, Christopher D., et al.
Publicado: (2014)

DNA Mismatch Repair Deficiency Detection in Colorectal Cancer by a New Microsatellite Instability Analysis System
por: Wu, Shafei, et al.
Publicado: (2020)

Early detection and prognosis prediction for colorectal cancer by circulating tumour DNA methylation haplotypes: A multicentre cohort study
por: Mo, Shaobo, et al.
Publicado: (2022)

Relationship between circulating tumour DNA and skeletal muscle stores at diagnosis of pancreatic ductal adenocarcinoma: a cross-sectional study
por: Hanna, Lauren, et al.
Publicado: (2023)

Modified primary tumour/vessel tumour/nodal tumour classification for patients with invasive ductal carcinoma of the breast
por: Hasebe, T, et al.
Publicado: (2011)

Preoperative neutrophil-to-lymphocyte ratio and tumor-related factors to predict lymph node metastasis in patients with pancreatic ductal adenocarcinoma (PDAC)
por: Tao, Lianyuan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_15qhevjholoqicv401ndbc00cq