Intracellular cholesterol transport inhibition Impairs autophagy flux by decreasing autophagosome–lysosome fusion

BACKGROUND: Autophagy is an intracellular degradation process crucial for homeostasis. During autophagy, a double-membrane autophagosome fuses with lysosome through SNARE machinery STX17 to form autolysosome for degradation of damaged organelle. Whereas defective autophagy enhances cholesterol accum...

Descripción completa

Detalles Bibliográficos
Autores principales: Maharjan, Yunash, Dutta, Raghbendra Kumar, Son, Jinbae, Wei, Xiaofan, Park, Channy, Kwon, Hyug Moo, Park, Raekil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701069/
https://www.ncbi.nlm.nih.gov/pubmed/36434621
http://dx.doi.org/10.1186/s12964-022-00942-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701069/
https://www.ncbi.nlm.nih.gov/pubmed/36434621
http://dx.doi.org/10.1186/s12964-022-00942-z

Ejemplares similares