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Intracellular cholesterol transport inhibition Impairs autophagy flux by decreasing autophagosome–lysosome fusion

BACKGROUND: Autophagy is an intracellular degradation process crucial for homeostasis. During autophagy, a double-membrane autophagosome fuses with lysosome through SNARE machinery STX17 to form autolysosome for degradation of damaged organelle. Whereas defective autophagy enhances cholesterol accum...

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Detalles Bibliográficos
Autores principales:	Maharjan, Yunash, Dutta, Raghbendra Kumar, Son, Jinbae, Wei, Xiaofan, Park, Channy, Kwon, Hyug Moo, Park, Raekil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701069/ https://www.ncbi.nlm.nih.gov/pubmed/36434621 http://dx.doi.org/10.1186/s12964-022-00942-z

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