Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice

BACKGROUND: SARS-CoV-2 Omicron variants are highly resistant to vaccine-induced immunity and human monoclonal antibodies. METHODS: We previously reported that two nanobodies, P17 and P86, potently neutralize SARS-CoV-2 VOCs. In this study, we modified these nanobodies into trimers, called TP17 and T...

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Detalles Bibliográficos
Autores principales: Nagata, Kayoko, Utsumi, Daichi, Asaka, Masamitsu N., Maeda, Ryota, Shirakawa, Kotaro, Kazuma, Yasuhiro, Nomura, Ryosuke, Horisawa, Yoshihito, Yanagida, Yohei, Kawai, Yugo, Sato, Kei, Yamaoka, Yutaro, Miyakawa, Kei, Ryo, Akihide, Yasutomi, Yasuhiro, Imura, Akihiro, Takaori-Kondo, Akifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701191/
https://www.ncbi.nlm.nih.gov/pubmed/36435945
http://dx.doi.org/10.1038/s43856-022-00213-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701191/
https://www.ncbi.nlm.nih.gov/pubmed/36435945
http://dx.doi.org/10.1038/s43856-022-00213-5

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