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Structural basis for lipid and copper regulation of the ABC transporter MsbA

A critical step in lipopolysaccharide (LPS) biogenesis involves flipping lipooligosaccharide, an LPS precursor, from the cytoplasmic to the periplasmic leaflet of the inner membrane, an operation carried out by the ATP-binding cassette transporter MsbA. Although LPS binding to the inner cavity of Ms...

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Detalles Bibliográficos
Autores principales: Lyu, Jixing, Liu, Chang, Zhang, Tianqi, Schrecke, Samantha, Elam, Nicklaus P., Packianathan, Charles, Hochberg, Georg K. A., Russell, David, Zhao, Minglei, Laganowsky, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701195/
https://www.ncbi.nlm.nih.gov/pubmed/36435815
http://dx.doi.org/10.1038/s41467-022-34905-2