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Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase
Oligosaccharyltransferase (OST) is the central enzyme of N-linked protein glycosylation. It catalyzes the transfer of a pre-assembled glycan, GlcNAc(2)Man(9)Glc(3), from a dolichyl-pyrophosphate donor to acceptor sites in secretory proteins in the lumen of the endoplasmic reticulum. Precise recognit...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701220/ https://www.ncbi.nlm.nih.gov/pubmed/36435935 http://dx.doi.org/10.1038/s41467-022-35067-x |