Cargando…

Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1

Forkhead box H1 (FoxH1) is an essential maternal pioneer factor during embryonic development that binds to specific GG/GT-containing DNA target sequences. Here we have determined high-resolution structures of three FoxH1 proteins (from human, frog and fish species) and four DNAs to clarify the way i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pluta, Radoslaw, Aragón, Eric, Prescott, Nicholas A., Ruiz, Lidia, Mees, Rebeca A., Baginski, Blazej, Flood, Julia R., Martin-Malpartida, Pau, Massagué, Joan, David, Yael, Macias, Maria J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701222/ https://www.ncbi.nlm.nih.gov/pubmed/36435807 http://dx.doi.org/10.1038/s41467-022-34925-y

Ejemplares similares

Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling
por: Aragón, Eric, et al.
Publicado: (2019)

Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α
por: Pous, Joan, et al.
Publicado: (2023)

Structures of the germline-specific Deadhead and thioredoxin T proteins from Drosophila melanogaster reveal unique features among thioredoxins
por: Freier, Regina, et al.
Publicado: (2021)

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
por: Martin-Malpartida, Pau, et al.
Publicado: (2017)

Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes
por: Ruiz, Lidia, et al.
Publicado: (2021)

Nodal-Dependent Mesendoderm Specification Requires the Combinatorial Activities of FoxH1 and Eomesodermin
por: Slagle, Christopher E., et al.
Publicado: (2011)

A comprehensive analysis of FOX family in HCC and experimental evidence to support the oncogenic role of FOXH1
por: Ouyang, Xiwu, et al.
Publicado: (2022)

FoxH1 Represses the Promoter Activity of cyp19a1a in the Ricefield Eel (Monopterus albus)
por: He, Zhi, et al.
Publicado: (2023)

FoxH1 represses miR-430 during early embryonic development of zebrafish via non-canonical regulation
por: Fischer, Patrick, et al.
Publicado: (2019)

Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left–Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry
por: Lenhart, Kari F., et al.
Publicado: (2013)

How mutant p53 empowers Foxh1 fostering leukaemogenesis?
por: Amelio, Ivano
Publicado: (2019)

FOXH1 Is Regulated by NANOG and LIN28 for Early-stage Reprogramming
por: Wang, Ling, et al.
Publicado: (2019)

Conformational landscape of multidomain SMAD proteins
por: Gomes, Tiago, et al.
Publicado: (2021)

William Henry Fox Talbot, pioneer of photography and man of science
Publicado: (1979)

FOXH1 promotes lung cancer progression by activating the Wnt/β-catenin signaling pathway
por: Zhang, Jun, et al.
Publicado: (2021)

Review of "Mosquito Net: A story of the pioneers of tropical medicine" by Cyril Fox
por: Knols, Bart GJ
Publicado: (2009)

Pioneer transcription factor FoxA is positioned on hypersensitive nucleosomes at active enhancers
por: Iwafuchi-Doi, Makiko, et al.
Publicado: (2013)

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway
por: González, Lorena, et al.
Publicado: (2023)

The mechanistic basis for chromatin regulation by pioneer transcription factors
por: Iwafuchi‐Doi, Makiko
Publicado: (2018)

Functional basis of primary succession: Traits of the pioneer microbes
por: Ni, Gaofeng, et al.
Publicado: (2022)

TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling
por: Guca, Ewelina, et al.
Publicado: (2018)

Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes
por: Caravaca, Juan Manuel, et al.
Publicado: (2013)

Foxh1/Nodal Defines Context-Specific Direct Maternal Wnt/β-Catenin Target Gene Regulation in Early Development
por: Afouda, Boni A., et al.
Publicado: (2020)

Structural Basis of Inhibition of the Pioneer Transcription Factor NF-Y by Suramin
por: Nardone, Valentina, et al.
Publicado: (2020)

Structural Analysis of the Pin1-CPEB1 interaction and its potential role in CPEB1 degradation
por: Schelhorn, Constanze, et al.
Publicado: (2015)

Large‐scale whole‐exome sequencing association study identifies FOXH1 gene and sphingolipid metabolism pathway influencing major depressive disorder
por: Zhou, Wei, et al.
Publicado: (2021)

Structural basis for nuclear import selectivity of pioneer transcription factor SOX2
por: Jagga, Bikshapathi, et al.
Publicado: (2021)

Flying foxes create extensive seed shadows and enhance germination success of pioneer plant species in deforested Madagascan landscapes
por: Oleksy, Ryszard, et al.
Publicado: (2017)

AB198. Nodal regulates the differentiation of iPS cells to male germ cells via Smad2/3, Oct4 and Foxh1 activation
por: Yang, Shi, et al.
Publicado: (2014)

RNArchitecture: a database and a classification system of RNA families, with a focus on structural information
por: Boccaletto, Pietro, et al.
Publicado: (2018)

Binding site plasticity in viral PPxY Late domain recognition by the third WW domain of human NEDD4
por: Iglesias-Bexiga, Manuel, et al.
Publicado: (2019)

Ludwik Hirszfeld: A pioneer of transfusion and immunology during the world wars and beyond
por: Czerwinski, Marcin, et al.
Publicado: (2021)

Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation
por: McFadden, Vanessa C., et al.
Publicado: (2017)

The pion's pioneers
Publicado: (1987)

Neutrino pioneer
Publicado: (2016)

Pioneers in neuroendocrinology
Publicado: (1979)

Pioneers in neuroendocrinology
Publicado: (1977)

Laser pioneers
por: Hecht, Jeff
Publicado: (1992)

Pioneers of science /
por: Lodge, Oliver, Sir, 1851-1940
Publicado: (1904)

Atomic pioneers
por: Hiebert, Ray, et al.
Publicado: (1970)

Cannot write session to /tmp/vufind_sessions/sess_pu06nt96qelm3c2if288s4kv8a