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Modified exosomal SIRPα variants alleviate white matter injury after intracerebral hemorrhage via microglia/macrophages

BACKGROUND: Despite limited efficiency, modulation of microglia/macrophages has shown to attenuate neuroinflammation after intracerebral hemorrhage (ICH). In this context, we evaluated the efficacy of modified exosomal signal regulatory protein α (SIRPα) variants (SIRPα-v Exos) in microglia/macropha...

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Detalles Bibliográficos
Autores principales: Gao, Xinjie, Yang, Heng, Xiao, Weiping, Su, Jiabin, Zhang, Yuwen, Wang, He, Ni, Wei, Gu, Yuxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701394/
https://www.ncbi.nlm.nih.gov/pubmed/36435797
http://dx.doi.org/10.1186/s40824-022-00311-4