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Paxlovid accelerates cartilage degeneration and senescence through activating endoplasmic reticulum stress and interfering redox homeostasis

BACKGROUND: The COVID-19 pandemic has become a huge threat to human health, infecting millions of people worldwide and causing enormous economic losses. Many novel small molecule drugs have been developed to treat patients with COVID-19, including Paxlovid, which block the synthesis of virus-related...

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Detalles Bibliográficos
Autores principales: Kong, Keyu, Chang, Yongyun, Qiao, Hua, Zhao, Chen, Chen, Xuzhuo, Rong, Kewei, Zhang, Pu, Jin, Minghao, Zhang, Jingwei, Li, Huiwu, Zhai, Zanjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701426/
https://www.ncbi.nlm.nih.gov/pubmed/36435786
http://dx.doi.org/10.1186/s12967-022-03770-4