Cargando…
Systematic generation and imaging of tandem repeats reveal base-pairing properties that promote RNA aggregation
A common pathological feature of RNAs containing expanded repeat sequences is their propensity to aggregate in cells. While some repeat RNA aggregates have been shown to cause toxicity by sequestering RNA-binding proteins, the molecular mechanism of aggregation remains unclear. Here, we devised an e...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701603/ https://www.ncbi.nlm.nih.gov/pubmed/36452875 http://dx.doi.org/10.1016/j.crmeth.2022.100334 |