CLK1/CLK2-driven signalling at the Leishmania kinetochore is captured by spatially referenced proximity phosphoproteomics

Kinetochores in the parasite Leishmania and related kinetoplastids appear to be unique amongst eukaryotes and contain protein kinases as core components. Using the kinetochore kinases KKT2, KKT3 and CLK2 as baits, we developed a BirA* proximity biotinylation methodology optimised for sensitivity, XL...

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Detalles Bibliográficos
Autores principales: Geoghegan, Vincent, Carnielli, Juliana B. T., Jones, Nathaniel G., Saldivia, Manuel, Antoniou, Sergios, Hughes, Charlotte, Neish, Rachel, Dowle, Adam, Mottram, Jeremy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701682/
https://www.ncbi.nlm.nih.gov/pubmed/36437406
http://dx.doi.org/10.1038/s42003-022-04280-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701682/
https://www.ncbi.nlm.nih.gov/pubmed/36437406
http://dx.doi.org/10.1038/s42003-022-04280-1

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