Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres

Telomerase reactivation is one of the hallmarks of cancer, which plays an important role in cellular immortalization and the development and progression of the tumor. Chemical telomerase inhibitors have been shown to trigger replicative senescence and apoptotic cell death both in vitro and in vivo....

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Detalles Bibliográficos
Autores principales: Maciejewska, Natalia, Olszewski, Mateusz, Jurasz, Jakub, Baginski, Maciej, Stasevych, Maryna, Zvarych, Viktor, Folini, Marco, Zaffaroni, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701690/
https://www.ncbi.nlm.nih.gov/pubmed/36437244
http://dx.doi.org/10.1038/s41419-022-05443-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701690/
https://www.ncbi.nlm.nih.gov/pubmed/36437244
http://dx.doi.org/10.1038/s41419-022-05443-y

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