Disrupting PTPRJ transmembrane-mediated oligomerization counteracts oncogenic receptor tyrosine kinase FLT3 ITD

The receptor protein tyrosine phosphatase (RPTP) PTPRJ (also known as DEP-1) has been identified as a negative regulator of the receptor tyrosine kinase FLT3 signalling in vitro. The inactivation of the PTPRJ gene in mice expressing the constitutively active, oncogenic receptor tyrosine kinase FLT3...

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Detalles Bibliográficos
Autores principales: Schwarz, Marie, Rizzo, Sophie, Paz, Walter Espinoza, Kresinsky, Anne, Thévenin, Damien, Müller, Jörg P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701752/
https://www.ncbi.nlm.nih.gov/pubmed/36452504
http://dx.doi.org/10.3389/fonc.2022.1017947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701752/
https://www.ncbi.nlm.nih.gov/pubmed/36452504
http://dx.doi.org/10.3389/fonc.2022.1017947

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