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Disrupting PTPRJ transmembrane-mediated oligomerization counteracts oncogenic receptor tyrosine kinase FLT3 ITD

The receptor protein tyrosine phosphatase (RPTP) PTPRJ (also known as DEP-1) has been identified as a negative regulator of the receptor tyrosine kinase FLT3 signalling in vitro. The inactivation of the PTPRJ gene in mice expressing the constitutively active, oncogenic receptor tyrosine kinase FLT3...

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Detalles Bibliográficos
Autores principales:	Schwarz, Marie, Rizzo, Sophie, Paz, Walter Espinoza, Kresinsky, Anne, Thévenin, Damien, Müller, Jörg P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701752/ https://www.ncbi.nlm.nih.gov/pubmed/36452504 http://dx.doi.org/10.3389/fonc.2022.1017947

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