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Deficiency in ST6GAL1, one of the two α2,6-sialyltransferases, has only a minor effect on the pathogenesis of prion disease
Prion diseases are a group of fatal neurodegenerative diseases caused by misfolding of the normal cellular form of the prion protein or PrP(C), into a disease-associated self-replicating state or PrP(Sc). PrP(C) and PrP(Sc) are posttranslationally modified with N-linked glycans, in which the termina...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702343/ https://www.ncbi.nlm.nih.gov/pubmed/36452458 http://dx.doi.org/10.3389/fmolb.2022.1058602 |