Cargando…

Establishment of transgenic pigs overexpressing human PKD2-D511V mutant

Numerous missense mutations have been reported in autosomal dominant polycystic kidney disease which is one of the most common renal genetic disorders. The underlying mechanism for cystogenesis is still elusive, partly due to the lack of suitable animal models. Currently, we tried to establish a por...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yuan, Xu, Saifei, Jin, Qiao, Luo, Jianing, Gao, Ce, Jayaprakash, Sakthidasan, Wang, Huanan, Zhuang, Lenan, He, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702356/ https://www.ncbi.nlm.nih.gov/pubmed/36452154 http://dx.doi.org/10.3389/fgene.2022.1059682

Ejemplares similares

Transcriptomic Prediction of Pig Liver-Enriched Gene 1 Functions in a Liver Cell Line
por: Zhang, Zhe, et al.
Publicado: (2020)

Identification of ADPKD-Related Genes and Pathways in Cells Overexpressing PKD2
por: Zhang, Zhe, et al.
Publicado: (2020)

Long Intergenic Non-protein Coding RNA 511 in Cancers
por: Wang, Xiao-Fei, et al.
Publicado: (2020)

Generation of heterozygous PKD1 mutant pigs exhibiting early-onset renal cyst formation
por: Watanabe, Masahito, et al.
Publicado: (2022)

Challenging Disease Ontology by Instances of Atypical PKHD1 and PKD1 Genetics
por: de Fallois, Jonathan, et al.
Publicado: (2021)

Skin-specific transgenic overexpression of ovine β-catenin in mice
por: Wang, Jiankui, et al.
Publicado: (2023)

MicroRNA-511 Inhibits Cellular Proliferation and Invasion in Colorectal Cancer by Directly Targeting Hepatoma-Derived Growth Factor
por: He, Saifei, et al.
Publicado: (2018)

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency
por: O'Brien, Jason M., et al.
Publicado: (2014)

GH Overexpression Alters Spermatic Cells MicroRNAome Profile in Transgenic Zebrafish
por: Domingues, William B., et al.
Publicado: (2021)

Adaptation of Gut Microbiome to Transgenic Pigs Secreting β-Glucanase, Xylanase, and Phytase
por: Mo, Jianxin, et al.
Publicado: (2021)

Overexpression of Rhodopsin or Its Mutants Leads to Energy Metabolism Dysfunction in 661w Cells
por: Liu, Yang, et al.
Publicado: (2022)

Identification of JPX-RABEP1 Pair as an Immune-Related Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension by Bioinformatics and Experimental Analyses
por: Gong, Qian, et al.
Publicado: (2022)

CRISPR/Cas9 Mutagenesis and Expression of Dominant Mutant Transgenes as Functional Genomic Approaches in Parasitic Nematodes
por: Lok, James B.
Publicado: (2019)

GANAB and PKD1 Variations in a 12 Years Old Female Patient With Early Onset of Autosomal Dominant Polycystic Kidney Disease
por: Waldrop, Elizabeth, et al.
Publicado: (2019)

A semi-automated motion-tracking analysis of locomotion speed in the C. elegans transgenics overexpressing beta-amyloid in neurons
por: Machino, Kevin, et al.
Publicado: (2014)

A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma
por: Mei, Yan, et al.
Publicado: (2020)

Pkd1 and Pkd2 Are Required for Normal Placental Development
por: Garcia-Gonzalez, Miguel A., et al.
Publicado: (2010)

Microarray dataset of transgenic rice overexpressing Abp57
por: Tan, Lay Wen, et al.
Publicado: (2017)

PKD1 Mono-Allelic Knockout Is Sufficient to Trigger Renal Cystogenesis in a Mini-Pig Model
por: He, Jin, et al.
Publicado: (2015)

Genomic Analysis Reveals Human-Mediated Introgression From European Commercial Pigs to Henan Indigenous Pigs
por: Wang, Kejun, et al.
Publicado: (2021)

Reducing YAP expression in Pkd1 mutant mice does not improve the cystic phenotype
por: Formica, Chiara, et al.
Publicado: (2020)

Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
por: Tsukiyama, Tomoyuki, et al.
Publicado: (2019)

High Resolution Melt analysis for mutation screening in PKD1 and PKD2
por: Bataille, Stanislas, et al.
Publicado: (2011)

Identified eleven exon variants in PKD1 and PKD2 genes that altered RNA splicing by minigene assay
por: Liu, Xuyan, et al.
Publicado: (2023)

Generation of Multi-Transgenic Pigs Using PiggyBac Transposons Co-expressing Pectinase, Xylanase, Cellulase, β-1.3-1.4-Glucanase and Phytase
por: Wang, Haoqiang, et al.
Publicado: (2020)

Overexpression of defense response genes in transgenic wheat enhances resistance to Fusarium head blight
por: Mackintosh, Caroline A., et al.
Publicado: (2006)

NEAT1/MALAT1/XIST/PKD--Hsa-Mir-101-3p--DLGAP5 Axis as a Novel Diagnostic and Prognostic Biomarker Associated With Immune Cell Infiltration in Bladder Cancer
por: Rao, Xiaosheng, et al.
Publicado: (2022)

Transgenic mice display hair loss and regrowth overexpressing mutant Hr gene
por: Zhu, Kuicheng, et al.
Publicado: (2017)

Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways
por: Koupepidou, Panayiota, et al.
Publicado: (2010)

p53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis
por: Li, Haili, et al.
Publicado: (2019)

Arrhythmogenic Hearts in PKD2 Mutant Mice Are Characterized by Cardiac Fibrosis, Systolic, and Diastolic Dysfunctions
por: Amirrad, Farideh, et al.
Publicado: (2021)

Identification of novel PKD1 and PKD2 mutations in a Chinese population with autosomal dominant polycystic kidney disease
por: Liu, Bei, et al.
Publicado: (2015)

Integrated Bioinformatics Analysis Reveals Marker Genes and Potential Therapeutic Targets for Pulmonary Arterial Hypertension
por: Li, Aoqi, et al.
Publicado: (2021)

PKD1 and PKD2 mutations in Slovenian families with autosomal dominant polycystic kidney disease
por: Vouk, Katja, et al.
Publicado: (2006)

Correction: cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways
por: Koupepidou, Panayiota, et al.
Publicado: (2011)

Corrigendum: Identification of novel PKD1 and PKD2 mutations in a Chinese population with autosomal dominant polycystic kidney disease
por: Liu, Bei, et al.
Publicado: (2016)

Polycystic Kidney Disease Caused by Bilineal Inheritance of Truncating PKD1 as Well as PKD2 Mutations
por: Losekoot, Monique, et al.
Publicado: (2020)

PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression
por: Lakhia, Ronak, et al.
Publicado: (2022)

Bioinformatics and Experimental Analyses Reveal Immune-Related LncRNA–mRNA Pair AC011483.1-CCR7 as a Biomarker and Therapeutic Target for Ischemic Cardiomyopathy
por: Jin, Qiao, et al.
Publicado: (2022)

Transgenic pigs designed to express human α-galactosidase to avoid humoral xenograft rejection
por: Zeyland, J., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vkurib8fi728i3v54nnm7pdrca