Oncolytic vaccinia virus expressing a bispecific T-cell engager enhances immune responses in EpCAM positive solid tumors

Insufficient intratumoral T-cell infiltration and lack of tumor-specific immune surveillance in tumor microenvironment (TME) hinder the progression of cancer immunotherapy. In this study, we explored a recombinant vaccinia virus encoding an EpCAM BiTE (VV-EpCAM BiTE) to modulate the immune suppressi...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Min, Zuo, Shuguang, Chen, Zhimin, Qian, Peng, Zhang, Yenan, Kong, Lingkai, Gao, Honglan, Wei, Jiwu, Dong, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702515/
https://www.ncbi.nlm.nih.gov/pubmed/36451817
http://dx.doi.org/10.3389/fimmu.2022.1017574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702515/
https://www.ncbi.nlm.nih.gov/pubmed/36451817
http://dx.doi.org/10.3389/fimmu.2022.1017574

Ejemplares similares