Maternal heterozygosity of Slc6a19 causes metabolic perturbation and congenital NAD deficiency disorder in mice

Nicotinamide adenine dinucleotide (NAD) is a key metabolite synthesised from vitamin B3 or tryptophan. Disruption of genes encoding NAD synthesis enzymes reduces NAD levels and causes congenital NAD deficiency disorder (CNDD), characterised by multiple congenital malformations. SLC6A19 (encoding B(0...

Descripción completa

Detalles Bibliográficos
Autores principales: Cuny, Hartmut, Bozon, Kayleigh, Kirk, Rosemary B., Sheng, Delicia Z., Bröer, Stefan, Dunwoodie, Sally L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702539/
https://www.ncbi.nlm.nih.gov/pubmed/36374036
http://dx.doi.org/10.1242/dmm.049647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702539/
https://www.ncbi.nlm.nih.gov/pubmed/36374036
http://dx.doi.org/10.1242/dmm.049647

Ejemplares similares