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Maternal heterozygosity of Slc6a19 causes metabolic perturbation and congenital NAD deficiency disorder in mice
Nicotinamide adenine dinucleotide (NAD) is a key metabolite synthesised from vitamin B3 or tryptophan. Disruption of genes encoding NAD synthesis enzymes reduces NAD levels and causes congenital NAD deficiency disorder (CNDD), characterised by multiple congenital malformations. SLC6A19 (encoding B(0...
Autores principales: | Cuny, Hartmut, Bozon, Kayleigh, Kirk, Rosemary B., Sheng, Delicia Z., Bröer, Stefan, Dunwoodie, Sally L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702539/ https://www.ncbi.nlm.nih.gov/pubmed/36374036 http://dx.doi.org/10.1242/dmm.049647 |
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