Cargando…

Evaluating the frequency and the impact of pharmacogenetic alleles in an ancestrally diverse Biobank population

BACKGROUND: Pharmacogenomics (PGx) aims to utilize a patient’s genetic data to enable safer and more effective prescribing of medications. The Clinical Pharmacogenetics Implementation Consortium (CPIC) provides guidelines with strong evidence for 24 genes that affect 72 medications. Despite strong e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Verma, Shefali S., Keat, Karl, Li, Binglan, Hoffecker, Glenda, Risman, Marjorie, Sangkuhl, Katrin, Whirl-Carrillo, Michelle, Dudek, Scott, Verma, Anurag, Klein, Teri E., Ritchie, Marylyn D., Tuteja, Sony
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703665/ https://www.ncbi.nlm.nih.gov/pubmed/36443877 http://dx.doi.org/10.1186/s12967-022-03745-5

Ejemplares similares

Pharmacogenomics Clinical Annotation Tool (PharmCAT)
por: Sangkuhl, Katrin, et al.
Publicado: (2019)

Evaluation of PrediXcan for prioritizing GWAS associations and predicting gene expression()
por: Li, Binglan, et al.
Publicado: (2018)

Influence of tissue context on gene prioritization for predicted transcriptome-wide association studies
por: Li, Binglan, et al.
Publicado: (2019)

A simulation study investigating power estimates in phenome-wide association studies
por: Verma, Anurag, et al.
Publicado: (2018)

Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group
por: Caudle, Kelly E., et al.
Publicado: (2019)

Variant Interpretation in Current Pharmacogenetic Testing
por: Luvsantseren, Sally, et al.
Publicado: (2020)

Collective feature selection to identify crucial epistatic variants
por: Verma, Shefali S., et al.
Publicado: (2018)

Another Round of “Clue” to Uncover the Mystery of Complex Traits
por: Verma, Shefali Setia, et al.
Publicado: (2018)

Performance of polygenic risk scores for cancer prediction in a racially diverse academic biobank
por: Wang, Louise, et al.
Publicado: (2022)

Prediction of CYP2D6 phenotype from genotype across world populations
por: Gaedigk, Andrea, et al.
Publicado: (2017)

From GWAS to Gene: Transcriptome-Wide Association Studies and Other Methods to Functionally Understand GWAS Discoveries
por: Li, Binglan, et al.
Publicado: (2021)

The Penn Medicine BioBank: Towards a Genomics-Enabled Learning Healthcare System to Accelerate Precision Medicine in a Diverse Population
por: Verma, Anurag, et al.
Publicado: (2022)

The Evolution of PharmVar
por: Gaedigk, Andrea, et al.
Publicado: (2018)

Implementing Pharmacogenetic Testing in Gastrointestinal Cancers (IMPACT-GI): Study Protocol for a Pragmatic Implementation Trial for Establishing DPYD and UGT1A1 Screening to Guide Chemotherapy Dosing
por: Varughese, Lisa A., et al.
Publicado: (2022)

An Evidence‐Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine
por: Whirl‐Carrillo, Michelle, et al.
Publicado: (2021)

Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202
por: Verma, Anurag, et al.
Publicado: (2017)

Standardizing terms for clinical pharmacogenetic test results: consensus terms from the Clinical Pharmacogenetics Implementation Consortium (CPIC)
por: Caudle, Kelly E., et al.
Publicado: (2017)

An Investigation of the Knowledge Overlap between Pharmacogenomics and Disease Genetics
por: Li, Binglan, et al.
Publicado: (2022)

The pharmacogenetics and pharmacogenomics knowledge base: accentuating the knowledge
por: Hernandez-Boussard, Tina, et al.
Publicado: (2008)

Investigation of ancestral alleles in the Bovinae subfamily
por: Naji, Maulana M., et al.
Publicado: (2021)

Drug Response Pharmacogenetics for 200,000 UK Biobank Participants
por: McInnes, Gregory, et al.
Publicado: (2021)

97856 Implementation of DPYD and UGT1A1 pharmacogenetic testing to guide chemotherapy dosing
por: Varughese, Lisa A., et al.
Publicado: (2021)

Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults
por: Li, Binglan, et al.
Publicado: (2021)

The Microcephalin Ancestral Allele in a Neanderthal Individual
por: Lari, Martina, et al.
Publicado: (2010)

Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols
por: Moore, Carrie B., et al.
Publicado: (2014)

Rare variants in drug target genes contributing to complex diseases, phenome-wide
por: Verma, Shefali Setia, et al.
Publicado: (2018)

Author Correction: Rare variants in drug target genes contributing to complex diseases, phenome-wide
por: Verma, Shefali Setia, et al.
Publicado: (2018)

The genetic and phenotypic correlates of mtDNA copy number in a multi-ancestry cohort
por: Zaidi, Arslan A., et al.
Publicado: (2023)

Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records
por: Crosslin, David R., et al.
Publicado: (2014)

Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process
por: Caudle, Kelly E., et al.
Publicado: (2014)

Preemptive pharmacogenetic testing to guide chemotherapy dosing in patients with gastrointestinal malignancies: a qualitative study of barriers to implementation
por: Lau-Min, Kelsey S., et al.
Publicado: (2022)

Exome-wide association analysis of CT imaging-derived hepatic fat in a medical biobank
por: Park, Joseph, et al.
Publicado: (2022)

The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database
por: Gaedigk, Andrea, et al.
Publicado: (2017)

PLATO software provides analytic framework for investigating complexity beyond genome-wide association studies
por: Hall, Molly A., et al.
Publicado: (2017)

PGxMine: Text mining for curation of PharmGKB
por: Lever, Jake, et al.
Publicado: (2020)

Using ODIN for a PharmGKB revalidation experiment
por: Rinaldi, Fabio, et al.
Publicado: (2012)

Pharmacogenetics of tenofovir renal toxicity in HIV-positive Southern Africans
por: Mateza, Somila, et al.
Publicado: (2023)

Ancestral Alleles in the Human Genome Based on Population Sequencing Data
por: Park, Leeyoung
Publicado: (2015)

Pharmacogenetic information in Swiss drug labels – a systematic analysis
por: Jeiziner, C., et al.
Publicado: (2020)

Biobank-scale inference of ancestral recombination graphs enables genealogical analysis of complex traits
por: Zhang, Brian C., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0gb89se7esgtbfcftlflf8lsj7