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Detailed stratified GWAS analysis for severe COVID-19 in four European populations

Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis o...

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Autores principales: Degenhardt, Frauke, Ellinghaus, David, Juzenas, Simonas, Lerga-Jaso, Jon, Wendorff, Mareike, Maya-Miles, Douglas, Uellendahl-Werth, Florian, ElAbd, Hesham, Rühlemann, Malte C, Arora, Jatin, Özer, Onur, Lenning, Ole Bernt, Myhre, Ronny, Vadla, May Sissel, Wacker, Eike M, Wienbrandt, Lars, Blandino Ortiz, Aaron, de Salazar, Adolfo, Garrido Chercoles, Adolfo, Palom, Adriana, Ruiz, Agustín, Garcia-Fernandez, Alba-Estela, Blanco-Grau, Albert, Mantovani, Alberto, Zanella, Alberto, Holten, Aleksander Rygh, Mayer, Alena, Bandera, Alessandra, Cherubini, Alessandro, Protti, Alessandro, Aghemo, Alessio, Gerussi, Alessio, Ramirez, Alfredo, Braun, Alice, Nebel, Almut, Barreira, Ana, Lleo, Ana, Teles, Ana, Kildal, Anders Benjamin, Biondi, Andrea, Caballero-Garralda, Andrea, Ganna, Andrea, Gori, Andrea, Glück, Andreas, Lind, Andreas, Tanck, Anja, Hinney, Anke, Carreras Nolla, Anna, Fracanzani, Anna Ludovica, Peschuck, Anna, Cavallero, Annalisa, Dyrhol-Riise, Anne Ma, Ruello, Antonella, Julià, Antonio, Muscatello, Antonio, Pesenti, Antonio, Voza, Antonio, Rando-Segura, Ariadna, Solier, Aurora, Schmidt, Axel, Cortes, Beatriz, Mateos, Beatriz, Nafria-Jimenez, Beatriz, Schaefer, Benedikt, Jensen, Björn, Bellinghausen, Carla, Maj, Carlo, Ferrando, Carlos, de la Horra, Carmen, Quereda, Carmen, Skurk, Carsten, Thibeault, Charlotte, Scollo, Chiara, Herr, Christian, Spinner, Christoph D, Gassner, Christoph, Lange, Christoph, Hu, Cinzia, Paccapelo, Cinzia, Lehmann, Clara, Angelini, Claudio, Cappadona, Claudio, Azuure, Clinton, Bianco, Cristiana, Cea, Cristina, Sancho, Cristina, Hoff, Dag Arne Lihaug, Galimberti, Daniela, Prati, Daniele, Haschka, David, Jiménez, David, Pestaña, David, Toapanta, David, Muñiz-Diaz, Eduardo, Azzolini, Elena, Sandoval, Elena, Binatti, Eleonora, Scarpini, Elio, Helbig, Elisa T, Casalone, Elisabetta, Urrechaga, Eloisa, Paraboschi, Elvezia Maria, Pontali, Emanuele, Reverter, Enric, Calderón, Enrique J, Navas, Enrique, Solligård, Erik, Contro, Ernesto, Arana-Arri, Eunate, Aziz, Fátima, Garcia, Federico, García Sánchez, Félix, Ceriotti, Ferruccio, Martinelli-Boneschi, Filippo, Peyvandi, Flora, Kurth, Florian, Blasi, Francesco, Malvestiti, Francesco, Medrano, Francisco J, Mesonero, Francisco, Rodriguez-Frias, Francisco, Hanses, Frank, Müller, Fredrik, Hemmrich-Stanisak, Georg, Bellani, Giacomo, Grasselli, Giacomo, Pezzoli, Gianni, Costantino, Giorgio, Albano, Giovanni, Cardamone, Giulia, Bellelli, Giuseppe, Citerio, Giuseppe, Foti, Giuseppe, Lamorte, Giuseppe, Matullo, Giuseppe, Baselli, Guido, Kurihara, Hayato, Neb, Holger, My, Ilaria, Kurth, Ingo, Hernández, Isabel, Pink, Isabell, de Rojas, Itziar, Galván-Femenia, Iván, Holter, Jan Cato, Afset, Jan Egil, Heyckendorf, Jan, Kässens, Jan, Damås, Jan Kristian, Rybniker, Jan, Altmüller, Janine, Ampuero, Javier, Martín, Javier, Erdmann, Jeanette, Banales, Jesus M, Badia, Joan Ramon, Dopazo, Joaquin, Schneider, Jochen, Bergan, Jonas, Barretina, Jordi, Walter, Jörn, Hernández Quero, Jose, Goikoetxea, Josune, Delgado, Juan, Guerrero, Juan M, Fazaal, Julia, Kraft, Julia, Schröder, Julia, Risnes, Kari, Banasik, Karina, Müller, Karl Erik, Gaede, Karoline I, Garcia-Etxebarria, Koldo, Tonby, Kristian, Heggelund, Lars, Izquierdo-Sanchez, Laura, Bettini, Laura Rachele, Sumoy, Lauro, Sander, Leif Erik, Lippert, Lena J, Terranova, Leonardo, Nkambule, Lindokuhle, Knopp, Lisa, Gustad, Lise Tuset, Garbarino, Lucia, Santoro, Luigi, Téllez, Luis, Roade, Luisa, Ostadreza, Mahnoosh, Intxausti, Maider, Kogevinas, Manolis, Riveiro-Barciela, Mar, Berger, Marc M, Schaefer, Marco, Niemi, Mari E K, Gutiérrez-Stampa, María A, Carrabba, Maria, Figuera Basso, Maria E, Valsecchi, Maria Grazia, Hernandez-Tejero, María, Vehreschild, Maria J G T, Manunta, Maria, Acosta-Herrera, Marialbert, D'Angiò, Mariella, Baldini, Marina, Cazzaniga, Marina, Grimsrud, Marit M, Cornberg, Markus, Nöthen, Markus M, Marquié, Marta, Castoldi, Massimo, Cordioli, Mattia, Cecconi, Maurizio, D'Amato, Mauro, Augustin, Max, Tomasi, Melissa, Boada, Mercè, Dreher, Michael, Seilmaier, Michael J, Joannidis, Michael, Wittig, Michael, Mazzocco, Michela, Ciccarelli, Michele, Rodríguez-Gandía, Miguel, Bocciolone, Monica, Miozzo, Monica, Imaz Ayo, Natale, Blay, Natalia, Chueca, Natalia, Montano, Nicola, Braun, Nicole, Ludwig, Nicole, Marx, Nikolaus, Martínez, Nilda, Cornely, Oliver A, Witzke, Oliver, Palmieri, Orazio, Faverio, Paola, Preatoni, Paoletta, Bonfanti, Paolo, Omodei, Paolo, Tentorio, Paolo, Castro, Pedro, Rodrigues, Pedro M, España, Pedro Pablo, Hoffmann, Per, Rosenstiel, Philip, Schommers, Philipp, Suwalski, Phillip, de Pablo, Raúl, Ferrer, Ricard, Bals, Robert, Gualtierotti, Roberta, Gallego-Durán, Rocío, Nieto, Rosa, Carpani, Rossana, Morilla, Rubén, Badalamenti, Salvatore, Haider, Sammra, Ciesek, Sandra, May, Sandra, Bombace, Sara, Marsal, Sara, Pigazzini, Sara, Klein, Sebastian, Pelusi, Serena, Wilfling, Sibylle, Bosari, Silvano, Volland, Sonja, Brunak, Søren, Raychaudhuri, Soumya, Schreiber, Stefan, Heilmann-Heimbach, Stefanie, Aliberti, Stefano, Ripke, Stephan, Dudman, Susanne, Wesse, Tanja, Zheng, Tenghao, Bahmer, Thomas, Eggermann, Thomas, Illig, Thomas, Brenner, Thorsten, Pumarola, Tomas, Feldt, Torsten, Folseraas, Trine, Gonzalez Cejudo, Trinidad, Landmesser, Ulf, Protzer, Ulrike, Hehr, Ute, Rimoldi, Valeria, Monzani, Valter, Skogen, Vegard, Keitel, Verena, Kopfnagel, Verena, Friaza, Vicente, Andrade, Victor, Moreno, Victor, Albrecht, Wolfgang, Peter, Wolfgang, Poller, Wolfgang, Farre, Xavier, Yi, Xiaoli, Wang, Xiaomin, Khodamoradi, Yascha, Karadeniz, Zehra, Latiano, Anna, Goerg, Siegfried, Bacher, Petra, Koehler, Philipp, Tran, Florian, Zoller, Heinz, Schulte, Eva C, Heidecker, Bettina, Ludwig, Kerstin U, Fernández, Javier, Romero-Gómez, Manuel, Albillos, Agustín, Invernizzi, Pietro, Buti, Maria, Duga, Stefano, Bujanda, Luis, Hov, Johannes R, Lenz, Tobias L, Asselta, Rosanna, de Cid, Rafael, Valenti, Luca, Karlsen, Tom H, Cáceres, Mario, Franke, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703941/
https://www.ncbi.nlm.nih.gov/pubmed/35848942
http://dx.doi.org/10.1093/hmg/ddac158