Design, and synthesis of selectively anticancer 4-cyanophenyl substituted thiazol-2-ylhydrazones

Cyclization of substituted thiosemicarbazones with α-bromo-4-cyanoacetophenone allows rapid single-step sustainable syntheses of 4-cyanophenyl-2-hydrazinylthiazoles libraries (30 examples, 66–79%). All show anticancer efficacy against HCT-116 and MCF-7 carcinoma cell lines with the majority being mo...

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Detalles Bibliográficos
Autores principales: Mehmood, Hasnain, Musa, Mustapha, Woodward, Simon, Hossan, Md Shahadat, Bradshaw, Tracey D., Haroon, Muhammad, Nortcliffe, Andrew, Akhtar, Tashfeen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704493/
https://www.ncbi.nlm.nih.gov/pubmed/36540407
http://dx.doi.org/10.1039/d2ra03226k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704493/
https://www.ncbi.nlm.nih.gov/pubmed/36540407
http://dx.doi.org/10.1039/d2ra03226k

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